Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine

Masato Ito, Ayaka Sakaguchi, Chika Kobayashi, Takao Ikariya

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which the unique chemoselectivity is originated from the bifunctional nature of ruthenium-NH moiety in the catalyst.

Original languageEnglish
Pages (from-to)290-291
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number2
DOIs
Publication statusPublished - Jan 17 2007

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Imides
Paroxetine
Hydrogenation
Ruthenium
Amides
Alcohols
Catalysts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine. / Ito, Masato; Sakaguchi, Ayaka; Kobayashi, Chika; Ikariya, Takao.

In: Journal of the American Chemical Society, Vol. 129, No. 2, 17.01.2007, p. 290-291.

Research output: Contribution to journalArticle

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