Chemosensitivity test for carcinoma of digestive organs

Yoshihiko Maehara, Shunji Kohnoe, Keizo Sugimachi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

For the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalSeminars in Surgical Oncology
Volume6
Issue number1
DOIs
Publication statusPublished - 1990

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Carcinoma
Subrenal Capsule Assay
Pyrimidine Nucleotides
Succinate Dehydrogenase
Liver Neoplasms
Antineoplastic Agents
Stomach Neoplasms
Colorectal Neoplasms
Neoplasms
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Chemosensitivity test for carcinoma of digestive organs. / Maehara, Yoshihiko; Kohnoe, Shunji; Sugimachi, Keizo.

In: Seminars in Surgical Oncology, Vol. 6, No. 1, 1990, p. 42-47.

Research output: Contribution to journalArticle

Maehara, Yoshihiko ; Kohnoe, Shunji ; Sugimachi, Keizo. / Chemosensitivity test for carcinoma of digestive organs. In: Seminars in Surgical Oncology. 1990 ; Vol. 6, No. 1. pp. 42-47.
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