Chemosensitivity test for carcinoma of digestive organs

Yoshihiko Maehara, Shunji Kohnoe, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

For the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalSeminars in Surgical Oncology
Volume6
Issue number1
DOIs
Publication statusPublished - 1990

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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