Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test

T. Mitsudomi, S. Kaneko, M. Tateishi, T. Yano, T. Ishida, S. Kohnoe, Y. Maehara, K. Sugimachi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We examined the chemosensitivity of 57 primary lung cancer specimens to 9 antitumor drugs, using the succinate dehydrogenase inhibition (SDI) test. Average succinate dehydrogenase (SD) activity was reduced to less than 50% by cis-diaminedichloroplatinum (II) (DDP), cyclophosphamide (CPA), carboquone (CQ), mitomycin C (MMC) and adriamycin (ADM). The lung cancer cells were relatively resistant to pepleomycin (PEP), 5-fluorouracil (5FU), vincristine (VCR) and vindesine (VDS). Small cell lung cancers, or early stage lung cancers, tended to be more sensitive to these antitumor drugs. However, differences in sensitivity with respect to either histology, staging or degree of differentiation were not statistically significant. Correlation of SD activity between 2 drugs was high among those which inhibit DNA synthesis (DDP, CPA, CQ or MMC), or between VCR and VDS (inhibitor of mitosis), however, the correlation between VDS and CPA, CQ or DDP was weak. The SDI test is a simple in vitro method readily available to aid in selecting drugs to treat patients with lung cancer.

Original languageEnglish
Pages (from-to)987-990
Number of pages4
JournalAnticancer research
Volume10
Issue number4
Publication statusPublished - Jan 1 1990

Fingerprint

Carbazilquinone
Succinate Dehydrogenase
Vindesine
Lung Neoplasms
Cyclophosphamide
Mitomycin
Vincristine
Antineoplastic Agents
Peplomycin
Small Cell Lung Carcinoma
Mitosis
Fluorouracil
Pharmaceutical Preparations
Doxorubicin
Histology
DNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Mitsudomi, T., Kaneko, S., Tateishi, M., Yano, T., Ishida, T., Kohnoe, S., ... Sugimachi, K. (1990). Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. Anticancer research, 10(4), 987-990.

Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. / Mitsudomi, T.; Kaneko, S.; Tateishi, M.; Yano, T.; Ishida, T.; Kohnoe, S.; Maehara, Y.; Sugimachi, K.

In: Anticancer research, Vol. 10, No. 4, 01.01.1990, p. 987-990.

Research output: Contribution to journalArticle

Mitsudomi, T, Kaneko, S, Tateishi, M, Yano, T, Ishida, T, Kohnoe, S, Maehara, Y & Sugimachi, K 1990, 'Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test', Anticancer research, vol. 10, no. 4, pp. 987-990.
Mitsudomi T, Kaneko S, Tateishi M, Yano T, Ishida T, Kohnoe S et al. Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. Anticancer research. 1990 Jan 1;10(4):987-990.
Mitsudomi, T. ; Kaneko, S. ; Tateishi, M. ; Yano, T. ; Ishida, T. ; Kohnoe, S. ; Maehara, Y. ; Sugimachi, K. / Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. In: Anticancer research. 1990 ; Vol. 10, No. 4. pp. 987-990.
@article{ccdc86e53be144b3ad56350d3b64f282,
title = "Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test",
abstract = "We examined the chemosensitivity of 57 primary lung cancer specimens to 9 antitumor drugs, using the succinate dehydrogenase inhibition (SDI) test. Average succinate dehydrogenase (SD) activity was reduced to less than 50{\%} by cis-diaminedichloroplatinum (II) (DDP), cyclophosphamide (CPA), carboquone (CQ), mitomycin C (MMC) and adriamycin (ADM). The lung cancer cells were relatively resistant to pepleomycin (PEP), 5-fluorouracil (5FU), vincristine (VCR) and vindesine (VDS). Small cell lung cancers, or early stage lung cancers, tended to be more sensitive to these antitumor drugs. However, differences in sensitivity with respect to either histology, staging or degree of differentiation were not statistically significant. Correlation of SD activity between 2 drugs was high among those which inhibit DNA synthesis (DDP, CPA, CQ or MMC), or between VCR and VDS (inhibitor of mitosis), however, the correlation between VDS and CPA, CQ or DDP was weak. The SDI test is a simple in vitro method readily available to aid in selecting drugs to treat patients with lung cancer.",
author = "T. Mitsudomi and S. Kaneko and M. Tateishi and T. Yano and T. Ishida and S. Kohnoe and Y. Maehara and K. Sugimachi",
year = "1990",
month = "1",
day = "1",
language = "English",
volume = "10",
pages = "987--990",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4",

}

TY - JOUR

T1 - Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test

AU - Mitsudomi, T.

AU - Kaneko, S.

AU - Tateishi, M.

AU - Yano, T.

AU - Ishida, T.

AU - Kohnoe, S.

AU - Maehara, Y.

AU - Sugimachi, K.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We examined the chemosensitivity of 57 primary lung cancer specimens to 9 antitumor drugs, using the succinate dehydrogenase inhibition (SDI) test. Average succinate dehydrogenase (SD) activity was reduced to less than 50% by cis-diaminedichloroplatinum (II) (DDP), cyclophosphamide (CPA), carboquone (CQ), mitomycin C (MMC) and adriamycin (ADM). The lung cancer cells were relatively resistant to pepleomycin (PEP), 5-fluorouracil (5FU), vincristine (VCR) and vindesine (VDS). Small cell lung cancers, or early stage lung cancers, tended to be more sensitive to these antitumor drugs. However, differences in sensitivity with respect to either histology, staging or degree of differentiation were not statistically significant. Correlation of SD activity between 2 drugs was high among those which inhibit DNA synthesis (DDP, CPA, CQ or MMC), or between VCR and VDS (inhibitor of mitosis), however, the correlation between VDS and CPA, CQ or DDP was weak. The SDI test is a simple in vitro method readily available to aid in selecting drugs to treat patients with lung cancer.

AB - We examined the chemosensitivity of 57 primary lung cancer specimens to 9 antitumor drugs, using the succinate dehydrogenase inhibition (SDI) test. Average succinate dehydrogenase (SD) activity was reduced to less than 50% by cis-diaminedichloroplatinum (II) (DDP), cyclophosphamide (CPA), carboquone (CQ), mitomycin C (MMC) and adriamycin (ADM). The lung cancer cells were relatively resistant to pepleomycin (PEP), 5-fluorouracil (5FU), vincristine (VCR) and vindesine (VDS). Small cell lung cancers, or early stage lung cancers, tended to be more sensitive to these antitumor drugs. However, differences in sensitivity with respect to either histology, staging or degree of differentiation were not statistically significant. Correlation of SD activity between 2 drugs was high among those which inhibit DNA synthesis (DDP, CPA, CQ or MMC), or between VCR and VDS (inhibitor of mitosis), however, the correlation between VDS and CPA, CQ or DDP was weak. The SDI test is a simple in vitro method readily available to aid in selecting drugs to treat patients with lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0025286418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025286418&partnerID=8YFLogxK

M3 - Article

C2 - 2382998

AN - SCOPUS:0025286418

VL - 10

SP - 987

EP - 990

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4

ER -