Chemotherapy for enterohemorrhagic Escherichia coli O157:H infection in a mouse model

Kazuaki Yoshimura, Jun Fujii, Hatsumi Taniguchi, Shin ichi Yoshida

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17 Citations (Scopus)

Abstract

The aim of this study is to evaluate the therapeutic effect of the antimicrobial agents, fosfomycin (FOM), minocycline (MINO), kanamycin (KM) and norfloxacin (NFLX) in the enterohemorrhagic Escherichia coli (EHEC) infected mouse model which we established previously (Infect. Immun. 62 (1994) 3447-3453). Each of the antimicrobial agents, 1/16 LD50, was given to the mice per os (p.o.) or intraperitoneally (i.p.) for 3 days after bacterial inoculation and then we observed their mortality rate for 2 weeks. The mortality rates of mice administered with MINO (p.o./i.p.), KM (p.o.), NFLX (p.o./i.p.) were significantly lower than those of the control group. Both the bacterial number and VT2c level in the feces of the FOM group were lower than those of the NFLX group on day 1, but reversed on day 3. In an in vitro experiment, each of the four drugs in combination with mitomycin C (MMC) caused a more significant decrease in the bacterial number than sole MMC, and they consequently indicated the suppressive effect on the release of VT2c. Copyright (C) 1999 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalFEMS Immunology and Medical Microbiology
Volume26
Issue number2
DOIs
Publication statusPublished - Nov 1 1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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