Chicken neuropeptide Y in the control of appetite and metabolism

Takashi Bungo, Jun ichi Shiraishi, Shin ichi Kawakami, D. Michael Denbow, Mitsuhiro Furuse

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the presence of neuropeptide Y (NPY) in the central nervous system of chickens was demonstrated in 1988, numerous studies have shown that NPY functions as a strong orexigenic factor in this species. Similar to mammals, central administration of NPY robustly stimulates ingestive behavior in chickens in a dose-dependent manner. NPY is one of the most abundant peptides in chicken brain. Fasting leads to increased NPY gene expression in this organ. Six receptor subtypes for NPY (Y1, Y2, Y4, Y5, Y6 and Y7) have been identified in chickens and their binding characteristics have been investigated. Although pharmacological studies prove that appetite stimulation by NPY in mammals is mediated by receptors Y1 and Y5, there are conflicting data between the receptor expressions and pharmacological effects in chickens. This review provides an overview of the orexigenic effect of NPY and interrelationship with appetite-related signals, and summarizes the role of the NPYergic system on feeding regulation in chickens.

Original languageEnglish
Title of host publicationNeuropeptide Y
Subtitle of host publicationMolecular Structure, Role in Food Intake and Direct/Indirect Effects
PublisherNova Science Publishers, Inc.
Pages1-24
Number of pages24
ISBN (Print)9781626184213
Publication statusPublished - Dec 1 2013

Fingerprint

Neuropeptide Y
Appetite
Metabolism
Chickens
Mammals
Pharmacology
Neurology
Gene expression
Fasting
Central Nervous System
Brain
Gene Expression
Peptides

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bungo, T., Shiraishi, J. I., Kawakami, S. I., Denbow, D. M., & Furuse, M. (2013). Chicken neuropeptide Y in the control of appetite and metabolism. In Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects (pp. 1-24). Nova Science Publishers, Inc..

Chicken neuropeptide Y in the control of appetite and metabolism. / Bungo, Takashi; Shiraishi, Jun ichi; Kawakami, Shin ichi; Denbow, D. Michael; Furuse, Mitsuhiro.

Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects. Nova Science Publishers, Inc., 2013. p. 1-24.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bungo, T, Shiraishi, JI, Kawakami, SI, Denbow, DM & Furuse, M 2013, Chicken neuropeptide Y in the control of appetite and metabolism. in Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects. Nova Science Publishers, Inc., pp. 1-24.
Bungo T, Shiraishi JI, Kawakami SI, Denbow DM, Furuse M. Chicken neuropeptide Y in the control of appetite and metabolism. In Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects. Nova Science Publishers, Inc. 2013. p. 1-24
Bungo, Takashi ; Shiraishi, Jun ichi ; Kawakami, Shin ichi ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Chicken neuropeptide Y in the control of appetite and metabolism. Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects. Nova Science Publishers, Inc., 2013. pp. 1-24
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