@article{f05e584b602a470a879058099dd1ee8d,
title = "Chiral dienolate chemistry in remote asymmetric induction: The allylation/Cope rearrangement sequence leading to γ-chiral α,β-unsaturated acid derivatives",
abstract = "The allylation of the dienolate derived from the chiral α, β- or β,γ-unsaturated imide followed by the Cope rearrangement is shown to effect the net remote asymmetric induction to create a new chirality of either configuration at the γ-position in high % de. The utility of this approach is shown in the asymmetric synthesis of the C6 side chain of zaragozic acid A. Copyright (C) 1996 Elsevier Science Ltd.",
author = "Katsuhiko Tomooka and Atsushi Nagasawa and Wei, {Shih Yi} and Takeshi Nakai",
note = "Funding Information: In summary, we have developed a general synthetic approach to the remote asymmetric induction which involves the asymmetric allylation of the chiral dienolates of the a, por P,y-unsaturated imides and the Cope rearrangement to afford the y-chiral-a, P-unsaturated acid derivatives in a highly stereocontrolled fashion. The applicability of the present approach to 1,3-remote stereocontrol has been demonstrated by the asymmetric synthesis of the C6 side chain of zaragozic acid A. Further works along the synthetic concept presented in this study is in progress.14 Acknowledgment: This work is partially supported by the Ministry of Education, Science, and Culture, Japan.",
year = "1996",
month = dec,
day = "2",
doi = "10.1016/S0040-4039(96)02077-1",
language = "English",
volume = "37",
pages = "8895--8898",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "49",
}