Abstract
The allylation of the dienolate derived from the chiral α, β- or β,γ-unsaturated imide followed by the Cope rearrangement is shown to effect the net remote asymmetric induction to create a new chirality of either configuration at the γ-position in high % de. The utility of this approach is shown in the asymmetric synthesis of the C6 side chain of zaragozic acid A. Copyright (C) 1996 Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 8895-8898 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 49 |
DOIs | |
Publication status | Published - Dec 2 1996 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry