Optically active benzimidazole (1) prepared from (R)-(-)-mandelic acid was found to serve as an effective chiral leaving group. For example, N-propionyl derivative of 1 reacted with amide-enolate to give optically active β-oxo amide (up to 65% ee) and the released 1 was recovered intact for reuse.
|Number of pages||3|
|Publication status||Published - Oct 1993|
All Science Journal Classification (ASJC) codes
- Organic Chemistry