Chirality transfer from epoxide to carbanion: Base-induced alkylation of O-carbamoyl cyanohydrins of β-silyl-α,β-epoxy aldehyde

Michiko Sasaki, Eiji Kawanishi, Yuri Shirakawa, Masatoshi Kawahata, Hyuma Masu, Kentaro Yamaguchi, Kei Takeda

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Enantioselective C-C bond formation at an α-position of a nitrile group with an external electrophile can be realized, although in modest ee, with the aid of both the concerted process of an epoxysilane rearrangement and a carbamoyl group.

Original languageEnglish
Pages (from-to)3061-3064
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number18
DOIs
Publication statusPublished - Jun 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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