Chitosan microparticles as injectable scaffolds for tissue engineering

Dunia Mercedes García Cruz, Jorge Luis Escobar Ivirico, Manuela Gomes, Jose Luis Gómez Ribelles, Manuel Salmerón Sánchez, Rui L. Reis, João F. Mano

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.

Original languageEnglish
Pages (from-to)378-380
Number of pages3
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume2
Issue number6
DOIs
Publication statusPublished - Aug 2008

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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