TY - JOUR
T1 - Chitosan microparticles as injectable scaffolds for tissue engineering
AU - Cruz, Dunia Mercedes García
AU - Ivirico, Jorge Luis Escobar
AU - Gomes, Manuela
AU - Ribelles, Jose Luis Gómez
AU - Sánchez, Manuel Salmerón
AU - Reis, Rui L.
AU - Mano, João F.
PY - 2008/8
Y1 - 2008/8
N2 - The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.
AB - The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.
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U2 - 10.1002/term.106
DO - 10.1002/term.106
M3 - Article
C2 - 18615778
AN - SCOPUS:60749091288
SN - 1932-6254
VL - 2
SP - 378
EP - 380
JO - Journal of Tissue Engineering and Regenerative Medicine
JF - Journal of Tissue Engineering and Regenerative Medicine
IS - 6
ER -