Abstract
A glycoprotein prepared from Chlorella vulgaris culture supernatant (CVS) is a biological response modifier (BRM) which exhibits protective activities against tumor metastasis and 5-fluorouracil-induced immunosuppression. We here show that oral administration of CVS prevented significantly the apoptosis of thymocytes in mice undergoing psychological stress in a communication box. Mice were exposed to the emotional stress for 14 days by witnessing other mice being exposed to foot-shock. The numbers in thymocytes, especially CD4+CD8+ population, were decreased significantly and apoptotic cells, as assessed by Annexin V expression, were reciprocally increased after the exposure to the psychological stress. C. vulgaris culture supernatant (CVS) administration significantly suppressed the increase in serum corticosterone level in the psychologically stressed mice. These results suggest that CVS prevents psychological stress and maintain homeostasis in the face of external environmental changes. Copyright (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 877-885 |
| Number of pages | 9 |
| Journal | International Journal of Immunopharmacology |
| Volume | 22 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 20 2000 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Pharmacology
Cite this
Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice. / Hasegawa, Takashi; Noda, Kiyoshi; Kumamoto, Shoichiro; Ando, Yotaro; Yamada, Akira; Yoshikai, Yasunobu.
In: International Journal of Immunopharmacology, Vol. 22, No. 11, 20.11.2000, p. 877-885.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice
AU - Hasegawa, Takashi
AU - Noda, Kiyoshi
AU - Kumamoto, Shoichiro
AU - Ando, Yotaro
AU - Yamada, Akira
AU - Yoshikai, Yasunobu
PY - 2000/11/20
Y1 - 2000/11/20
N2 - A glycoprotein prepared from Chlorella vulgaris culture supernatant (CVS) is a biological response modifier (BRM) which exhibits protective activities against tumor metastasis and 5-fluorouracil-induced immunosuppression. We here show that oral administration of CVS prevented significantly the apoptosis of thymocytes in mice undergoing psychological stress in a communication box. Mice were exposed to the emotional stress for 14 days by witnessing other mice being exposed to foot-shock. The numbers in thymocytes, especially CD4+CD8+ population, were decreased significantly and apoptotic cells, as assessed by Annexin V expression, were reciprocally increased after the exposure to the psychological stress. C. vulgaris culture supernatant (CVS) administration significantly suppressed the increase in serum corticosterone level in the psychologically stressed mice. These results suggest that CVS prevents psychological stress and maintain homeostasis in the face of external environmental changes. Copyright (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
AB - A glycoprotein prepared from Chlorella vulgaris culture supernatant (CVS) is a biological response modifier (BRM) which exhibits protective activities against tumor metastasis and 5-fluorouracil-induced immunosuppression. We here show that oral administration of CVS prevented significantly the apoptosis of thymocytes in mice undergoing psychological stress in a communication box. Mice were exposed to the emotional stress for 14 days by witnessing other mice being exposed to foot-shock. The numbers in thymocytes, especially CD4+CD8+ population, were decreased significantly and apoptotic cells, as assessed by Annexin V expression, were reciprocally increased after the exposure to the psychological stress. C. vulgaris culture supernatant (CVS) administration significantly suppressed the increase in serum corticosterone level in the psychologically stressed mice. These results suggest that CVS prevents psychological stress and maintain homeostasis in the face of external environmental changes. Copyright (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0033768788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033768788&partnerID=8YFLogxK
U2 - 10.1016/S0192-0561(00)00049-7
DO - 10.1016/S0192-0561(00)00049-7
M3 - Article
C2 - 11090696
AN - SCOPUS:0033768788
VL - 22
SP - 877
EP - 885
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 11
ER -