Abstract
The aim of the present study was to determine whether the sedative effects of L-proline are associated with the modulation of cholinergic neurotransmission. We investigated the effect of co-injection of L-proline with scopolamine, a Muscarinic Acetylcholine Receptor (M-AChR) antagonist, on behavior of neonatal chicks under isolation-induced stress. Intracerebroventricular (i.c.v.) injection of L-proline reduced spontaneous activity and the number of distress vocalizations, while co-injected scopolamine did not attenuate this effect implying that the M-AChR was not involved in the sedative effects induced by L-proline. In addition, the effect of L-proline on acetylcholineesterase activity in the telencephalon and diencephalon of chicks was investigated. No significant changes m acetylcholineesterase activity were observed in either the telencephalon or diencephalon. These results indicate that the sedative effects induced by L-proline are not mediated by the cholinergic system.
| Original language | English |
|---|---|
| Pages (from-to) | 1207-1211 |
| Number of pages | 5 |
| Journal | Journal of Animal and Veterinary Advances |
| Volume | 8 |
| Issue number | 6 |
| Publication status | Published - 2009 |
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- veterinary(all)