Cholinergic neurotransmission is not involved in sedation induced by L-proline in neonatal chicks

K. Hamasu, K. Shigemi, Y. Tsuneyoshi, H. Sato, D. M. Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the present study was to determine whether the sedative effects of L-proline are associated with the modulation of cholinergic neurotransmission. We investigated the effect of co-injection of L-proline with scopolamine, a Muscarinic Acetylcholine Receptor (M-AChR) antagonist, on behavior of neonatal chicks under isolation-induced stress. Intracerebroventricular (i.c.v.) injection of L-proline reduced spontaneous activity and the number of distress vocalizations, while co-injected scopolamine did not attenuate this effect implying that the M-AChR was not involved in the sedative effects induced by L-proline. In addition, the effect of L-proline on acetylcholineesterase activity in the telencephalon and diencephalon of chicks was investigated. No significant changes m acetylcholineesterase activity were observed in either the telencephalon or diencephalon. These results indicate that the sedative effects induced by L-proline are not mediated by the cholinergic system.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalJournal of Animal and Veterinary Advances
Volume8
Issue number6
Publication statusPublished - Nov 11 2009

Fingerprint

cholinergic agents
sedation
Proline
Synaptic Transmission
Cholinergic Agents
proline
chicks
sedatives
Hypnotics and Sedatives
scopolamine
Diencephalon
Telencephalon
Scopolamine Hydrobromide
cholinergic receptors
Muscarinic Receptors
injection
Injections
Cholinergic Antagonists
distress
vocalization

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • veterinary(all)

Cite this

Cholinergic neurotransmission is not involved in sedation induced by L-proline in neonatal chicks. / Hamasu, K.; Shigemi, K.; Tsuneyoshi, Y.; Sato, H.; Denbow, D. M.; Furuse, Mitsuhiro.

In: Journal of Animal and Veterinary Advances, Vol. 8, No. 6, 11.11.2009, p. 1207-1211.

Research output: Contribution to journalArticle

Hamasu, K. ; Shigemi, K. ; Tsuneyoshi, Y. ; Sato, H. ; Denbow, D. M. ; Furuse, Mitsuhiro. / Cholinergic neurotransmission is not involved in sedation induced by L-proline in neonatal chicks. In: Journal of Animal and Veterinary Advances. 2009 ; Vol. 8, No. 6. pp. 1207-1211.
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