Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate

Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chondrocyte dedifferentiation during subculture prevents cartilage tissue engineering. The dedifferentiation is generally caused by cell spreading and trypsin treatment. Thus, it is expected that chondrocytes maintain their specific functions when the cells are subcultured on a substrate that can suppress cell spreading and allow the cells to detach without trypsin treatment. Here, we showed that thermoresponsive poly(2-methoxyethyl acrylate) and analogous polymers can be used to suppress cell spreading and detachment without trypsin treatment.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalChemistry Letters
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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