Chromosomal defects and survival in patients with adult T-cell leukemia/ lymphoma after allogeneic HSCT

Nobuaki Nakano, Atae Utsunomiya, Keitaro Matsuo, Noriaki Yoshida, Masao Seto, Kouichi Ohshima, Hiroshi Fujiwara, Shigeo Fuji, Yoshifusa Takatsuka, Ayumu Ito, Toshihiro Miyamoto, Youko Suehiro, Hirohisa Nakamae, Yasushi Sawayama, Mitsuhiro Yuasa, Yasuhiko Miyazaki, Shuichi Ota, Kazunori Imada, Takahiro Fukuda, Tatsuo IchinoheYoshiko Atsuta, Koji Kato

Research output: Contribution to journalArticlepeer-review

Abstract

Adult T-cell leukemia/lymphoma (ATL) cells frequently exhibit chromosomal abnormalities, including numerical aberrations and structural defects. However, no studies have examined the correlation between these abnormalities and survival in patients with ATL after allogeneic HSCT (allo-HSCT). In this study, 300 patients with ATL (median age, 55 years; range, 24-74) who were registered in a Japanese nationwide registry database were analyzed. The majority (n =183) had acute ATL. Specimens for chromosomal analysis were collected from bone marrow (n = 166), lymph nodes (n = 86), peripheral blood (n = 41), and other locations (n = 7). In survival analyses, breakpoints at 2q (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.12-2.38; P =.012) and 5q (HR, 2.18; 95% CI, 1.25-3.80; P =.006) were significantly poor prognostic factors for overall survival (OS). In terms of ATL-related death, loss of chromosome 14 and breakpoints at 3p, 1q, 5q, and 6q were extracted as significantly poor prognostic factors. Moreover, complex karyotypes were associated with ATL-related death. This study of the survival impact of chromosomal abnormalities in patients with ATL after allo-HSCT demonstrated that several structural breakpoints were independent risk factors for OS and ATL-related death.

Original languageEnglish
Pages (from-to)475-486
Number of pages12
JournalBlood Advances
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 26 2021

All Science Journal Classification (ASJC) codes

  • Hematology

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