Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas

Toshiro Imamura, Takahiro Arima, Hidenori Kato, Shingo Miyamoto, Takehiko Sasazuki, Norio Wake

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Forty‐two endometrial carcinomas of various stages of progression were analyzed to search for loss of chromosomal regions and for point mutations of ras genes and amplification of Int‐2 gene. This approach is particularly favorable for observation of genetic events and their significance in the process of neoplastic conversion by considering the clinico‐pathological characteristics of each tumor. At least 3 genetic events, including 18q, 17p deletions, and point mutations at codon 12 of the K‐ras gene, are implicated in the development of endometrial carcinomas. Likely targets for allelic losses on chromosomes 18q and 17p are the DCC gene and the p53 gene sequences, respectively. Overall numbers of allelic losses in individual tumors appeared to increase in case of advanced stage tumors, thereby indicating the association of allelic loss accumulation with tumor progression. The genetic features seen in 2 juveniletype adenocarcinomas and 2 clear‐cell carcinomas suggested the possibility that etiological factors providing selective pressure for particular mutation sub‐sets during carcinogenesis are probably heterogeneous.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Cancer
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 1992

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Gene Deletion
Endometrial Neoplasms
Loss of Heterozygosity
Mutation
Point Mutation
DCC Genes
Neoplasms
Neoplastic Processes
ras Genes
Gene Amplification
Sequence Deletion
p53 Genes
Codon
Genes
Carcinogenesis
Adenocarcinoma
Chromosomes
Observation
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas. / Imamura, Toshiro; Arima, Takahiro; Kato, Hidenori; Miyamoto, Shingo; Sasazuki, Takehiko; Wake, Norio.

In: International Journal of Cancer, Vol. 51, No. 1, 01.01.1992, p. 47-52.

Research output: Contribution to journalArticle

Imamura, T, Arima, T, Kato, H, Miyamoto, S, Sasazuki, T & Wake, N 1992, 'Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas', International Journal of Cancer, vol. 51, no. 1, pp. 47-52. https://doi.org/10.1002/ijc.2910510110
Imamura, Toshiro ; Arima, Takahiro ; Kato, Hidenori ; Miyamoto, Shingo ; Sasazuki, Takehiko ; Wake, Norio. / Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas. In: International Journal of Cancer. 1992 ; Vol. 51, No. 1. pp. 47-52.
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