TY - JOUR
T1 - Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats
AU - Moriya, Takahiro
AU - Fukushima, Tatsuto
AU - Shimazoe, Takao
AU - Shibata, Shigenobu
AU - Watanabe, Shigenori
PY - 1996/4/19
Y1 - 1996/4/19
N2 - The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.
AB - The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.
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U2 - 10.1016/0304-3940(96)12565-9
DO - 10.1016/0304-3940(96)12565-9
M3 - Article
C2 - 8859907
AN - SCOPUS:0029931989
VL - 208
SP - 129
EP - 132
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -