Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Koji Chikama, Hidetaka Yamada, Tatsuo Tsukamoto, Kosuke Kajitani, Yusaku Nakabeppu, Naohisa Uchimura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment affect neurogenesis in adult mouse hippocampus. Animals were administered olanzapine, quetiapine, clozapine, risperidone, aripiprazole, or haloperidol via the osmotic minipump for 21 days and then injected with 5-bromo-2′-deoxyuridine (BrdU) to label mitotic cells. BrdU-positive cells in the hippocampus were quantified by stereology. Aripiprazole, quetiapine, clozapine, and olanzapine significantly increased density of BrdU-positive cells in the hippocampus. Interestingly, other antipsychotic drugs had tendency to increasing BrdU-positive cells, whereas haloperidol had propensity to decrease with a marginal significance. These results suggest that differences of neurogenesis among these drugs may, at least in part, account for their pharmacological profiles.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalBrain Research
Volume1676
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Neurogenesis
Haloperidol
Bromodeoxyuridine
olanzapine
Antipsychotic Agents
Hippocampus
Clozapine
Neuronal Plasticity
Risperidone
Schizophrenia
Pharmacology
Pharmaceutical Preparations
Aripiprazole
Quetiapine Fumarate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse. / Chikama, Koji; Yamada, Hidetaka; Tsukamoto, Tatsuo; Kajitani, Kosuke; Nakabeppu, Yusaku; Uchimura, Naohisa.

In: Brain Research, Vol. 1676, 01.12.2017, p. 77-82.

Research output: Contribution to journalArticle

Chikama, Koji ; Yamada, Hidetaka ; Tsukamoto, Tatsuo ; Kajitani, Kosuke ; Nakabeppu, Yusaku ; Uchimura, Naohisa. / Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse. In: Brain Research. 2017 ; Vol. 1676. pp. 77-82.
@article{92c038d8dc59491dbfd6b4f1000177da,
title = "Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse",
abstract = "It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment affect neurogenesis in adult mouse hippocampus. Animals were administered olanzapine, quetiapine, clozapine, risperidone, aripiprazole, or haloperidol via the osmotic minipump for 21 days and then injected with 5-bromo-2′-deoxyuridine (BrdU) to label mitotic cells. BrdU-positive cells in the hippocampus were quantified by stereology. Aripiprazole, quetiapine, clozapine, and olanzapine significantly increased density of BrdU-positive cells in the hippocampus. Interestingly, other antipsychotic drugs had tendency to increasing BrdU-positive cells, whereas haloperidol had propensity to decrease with a marginal significance. These results suggest that differences of neurogenesis among these drugs may, at least in part, account for their pharmacological profiles.",
author = "Koji Chikama and Hidetaka Yamada and Tatsuo Tsukamoto and Kosuke Kajitani and Yusaku Nakabeppu and Naohisa Uchimura",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.brainres.2017.09.006",
language = "English",
volume = "1676",
pages = "77--82",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

AU - Chikama, Koji

AU - Yamada, Hidetaka

AU - Tsukamoto, Tatsuo

AU - Kajitani, Kosuke

AU - Nakabeppu, Yusaku

AU - Uchimura, Naohisa

PY - 2017/12/1

Y1 - 2017/12/1

N2 - It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment affect neurogenesis in adult mouse hippocampus. Animals were administered olanzapine, quetiapine, clozapine, risperidone, aripiprazole, or haloperidol via the osmotic minipump for 21 days and then injected with 5-bromo-2′-deoxyuridine (BrdU) to label mitotic cells. BrdU-positive cells in the hippocampus were quantified by stereology. Aripiprazole, quetiapine, clozapine, and olanzapine significantly increased density of BrdU-positive cells in the hippocampus. Interestingly, other antipsychotic drugs had tendency to increasing BrdU-positive cells, whereas haloperidol had propensity to decrease with a marginal significance. These results suggest that differences of neurogenesis among these drugs may, at least in part, account for their pharmacological profiles.

AB - It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment affect neurogenesis in adult mouse hippocampus. Animals were administered olanzapine, quetiapine, clozapine, risperidone, aripiprazole, or haloperidol via the osmotic minipump for 21 days and then injected with 5-bromo-2′-deoxyuridine (BrdU) to label mitotic cells. BrdU-positive cells in the hippocampus were quantified by stereology. Aripiprazole, quetiapine, clozapine, and olanzapine significantly increased density of BrdU-positive cells in the hippocampus. Interestingly, other antipsychotic drugs had tendency to increasing BrdU-positive cells, whereas haloperidol had propensity to decrease with a marginal significance. These results suggest that differences of neurogenesis among these drugs may, at least in part, account for their pharmacological profiles.

UR - http://www.scopus.com/inward/record.url?scp=85029601184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029601184&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2017.09.006

DO - 10.1016/j.brainres.2017.09.006

M3 - Article

C2 - 28899760

AN - SCOPUS:85029601184

VL - 1676

SP - 77

EP - 82

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -