Chronic graft-versus-host disease following umbilical cord blood transplantation: Retrospective survey involving 1072 patients in Japan

Hiroto Narimatsu, Shigesaburo Miyakoshi, Takuhiro Yamaguchi, Masahiro Kami, Tomoko Matsumura, Koichiro Yuji, Naoko Murashige, Eiji Kusumi, Yuko Kodama, Tsunehiko Komatsu, Hisashi Sakamaki, Yasushi Kouzai, Masaya Okada, Yuko Osugi, Ryoji Kobayashi, Masami Inoue, Satoshi Takahashi, Shunro Kai, Koji Kato, Tokiko Inoue-NagamuraShuichi Taniguchi, Shunichi Kato

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We have little information on chronic graft-versus-host disease (GVHD) after cord blood transplantation (CBT). We investigated its clinical features in 1072 Japanese patients with hematologic malignancies who received a transplant through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 years after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated with both overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD: higher patient body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis, and development of grades II to IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects.

Original languageEnglish
Pages (from-to)2579-2582
Number of pages4
JournalBlood
Volume112
Issue number6
DOIs
Publication statusPublished - Sep 15 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Narimatsu, H., Miyakoshi, S., Yamaguchi, T., Kami, M., Matsumura, T., Yuji, K., Murashige, N., Kusumi, E., Kodama, Y., Komatsu, T., Sakamaki, H., Kouzai, Y., Okada, M., Osugi, Y., Kobayashi, R., Inoue, M., Takahashi, S., Kai, S., Kato, K., ... Kato, S. (2008). Chronic graft-versus-host disease following umbilical cord blood transplantation: Retrospective survey involving 1072 patients in Japan. Blood, 112(6), 2579-2582. https://doi.org/10.1182/blood-2007-11-118893