Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

Noriaki Kawano, Hisashi Gondo, Tomohiko Kamimura, Kenichi Aoki, Tadafumi Iino, Fumihiko Ishikawa, Toshihiro Miyamoto, Koji Nagafuji, Kazuya Shimoda, Shin Hayashi, Teruhisa Otsuka, Yukumasa Kazuyama, Mine Harada

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Abstract

We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.

Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalInternational journal of hematology
Volume78
Issue number4
DOIs
Publication statusPublished - Nov 2003

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All Science Journal Classification (ASJC) codes

  • Hematology

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