Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

Noriaki Kawano; Hisashi Gondo; Tomohiko Kamimura; Kenichi Aoki; Tadafumi Iino; Fumihiko Ishikawa; Toshihiro Miyamoto; Koji Nagafuji; Kazuya Shimoda; Shin Hayashi; Teruhisa Otsuka; Yukumasa Kazuyama; Mine Harada

doi:10.1007/BF02983564

Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

Noriaki Kawano, Hisashi Gondo, Tomohiko Kamimura, Kenichi Aoki, Tadafumi Iino, Fumihiko Ishikawa, Toshihiro Miyamoto, Koji Nagafuji, Kazuya Shimoda, Shin Hayashi, Teruhisa Otsuka, Yukumasa Kazuyama, Mine Harada

Internal Medicine

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17 Citations (Scopus)

Abstract

We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.

Original language	English
Pages (from-to)	370-373
Number of pages	4
Journal	International journal of hematology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1007/BF02983564
Publication status	Published - Nov 2003

All Science Journal Classification (ASJC) codes

Hematology

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Kawano, N., Gondo, H., Kamimura, T., Aoki, K., Iino, T., Ishikawa, F., Miyamoto, T., Nagafuji, K., Shimoda, K., Hayashi, S., Otsuka, T., Kazuyama, Y., & Harada, M. (2003). Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients. International journal of hematology, 78(4), 370-373. https://doi.org/10.1007/BF02983564

Kawano, N, Gondo, H, Kamimura, T, Aoki, K, Iino, T, Ishikawa, F, Miyamoto, T, Nagafuji, K, Shimoda, K, Hayashi, S, Otsuka, T, Kazuyama, Y & Harada, M 2003, 'Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients', International journal of hematology, vol. 78, no. 4, pp. 370-373. https://doi.org/10.1007/BF02983564

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title = "Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients",

abstract = "We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.",

author = "Noriaki Kawano and Hisashi Gondo and Tomohiko Kamimura and Kenichi Aoki and Tadafumi Iino and Fumihiko Ishikawa and Toshihiro Miyamoto and Koji Nagafuji and Kazuya Shimoda and Shin Hayashi and Teruhisa Otsuka and Yukumasa Kazuyama and Mine Harada",

note = "Funding Information: This research was supported by a Grant-in-Aid for Research on the Human Genome, Tissue Engineering, and Food Biotechnology from the Ministry of Health, Labor, and Welfare. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2003",

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doi = "10.1007/BF02983564",

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AU - Aoki, Kenichi

AU - Iino, Tadafumi

AU - Ishikawa, Fumihiko

AU - Miyamoto, Toshihiro

AU - Nagafuji, Koji

AU - Shimoda, Kazuya

AU - Hayashi, Shin

AU - Otsuka, Teruhisa

AU - Kazuyama, Yukumasa

AU - Harada, Mine

N1 - Funding Information: This research was supported by a Grant-in-Aid for Research on the Human Genome, Tissue Engineering, and Food Biotechnology from the Ministry of Health, Labor, and Welfare. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

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Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

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