Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats

Takayuki Hida, Eiki Takahashi, Kodo Shikata, Tomoko Hirohashi, Toru Sawai, Takashi Seiki, Hirokazu Tanaka, Takatoshi Kawai, Osamu Ito, Toru Arai, Akira Yokoi, Tetsuya Hirakawa, Hiroo Ogura, Takeshi Nagasu, Norimasa Miyamoto, Junro Kuromitsu

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Bolus-administered intracerebroventricular (ICV) relaxin-3 has been reported to increase feeding. In this study, to examine the role of relaxin-3 signaling in energy homeostasis, we studied the effects of chronically administered ICV relaxin-3 on body weight gain and locomotor activity in rats. Two groups of animals received vehicle or relaxin-3 at 600 pmol/head/day, delivered with Alzet osmotic minipumps. In animals receiving relaxin-3, food consumption and weight gain were statistically significantly higher than those in the vehicle group during the 14-day infusion. During the light phase on days 2 and 7 and the dark phase on days 3 and 8, there was no difference in locomotor activity between the two groups. Plasma concentrations of leptin and insulin in rats chronically injected with relaxin-3 were significantly higher than in the vehicle-injected controls. These results indicate that relaxin-3 up-regulates food intake, leading to an increase of body weight and that relaxin-3 antagonists might be candidate antiobesity agents.

Original languageEnglish
Pages (from-to)147-158
Number of pages12
JournalJournal of Receptors and Signal Transduction
Volume26
Issue number3
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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