TY - JOUR
T1 - Chronic l-tyrosine alters the locomotor activity and brain monoamine levels in Roborovskii hamsters
AU - Kabuki, Yusuke
AU - Shigemi, Kazutaka
AU - Hamasu, Kousuke
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Society of Pet Animal Nutrition and MEXT City Area Program (Development Stage).
PY - 2011/1/13
Y1 - 2011/1/13
N2 - The Roborovskii hamster (Phodopus roborovskii) has high locomotor activity (hyperactivity) and low dopamine levels in the brain compared with the congeneric Djungarian hamster (Phodopus sungorus). To clarify the efficacy of dietary l-tyrosine in ameliorating signs of hyperactivity, we investigated the effects of chronic administration of l-tyrosine, the primary precursor of dopamine, on locomotor activity and brain monoamine levels in Roborovskii hamsters. Chronic supplementastion of l-tyrosine had no effect on locomotor activity in the open field, but did decrease locomotor activity in the home cage. Tyrosine increased dopamine and norepinephrine turnover rates and decreased in serotonin turnover rate in the brain. These findings suggest that long-term feeding of l-tyrosine may be effective in ameliorating signs of hyperactivity.
AB - The Roborovskii hamster (Phodopus roborovskii) has high locomotor activity (hyperactivity) and low dopamine levels in the brain compared with the congeneric Djungarian hamster (Phodopus sungorus). To clarify the efficacy of dietary l-tyrosine in ameliorating signs of hyperactivity, we investigated the effects of chronic administration of l-tyrosine, the primary precursor of dopamine, on locomotor activity and brain monoamine levels in Roborovskii hamsters. Chronic supplementastion of l-tyrosine had no effect on locomotor activity in the open field, but did decrease locomotor activity in the home cage. Tyrosine increased dopamine and norepinephrine turnover rates and decreased in serotonin turnover rate in the brain. These findings suggest that long-term feeding of l-tyrosine may be effective in ameliorating signs of hyperactivity.
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U2 - 10.1016/j.neulet.2010.10.077
DO - 10.1016/j.neulet.2010.10.077
M3 - Article
C2 - 21056630
AN - SCOPUS:78650512542
SN - 0304-3940
VL - 488
SP - 45
EP - 48
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -