Abstract
We describe the case of a 10-year old girl with chronic myelomonocytic leukaemia with the chromosomal translocation t(8;9)(p11;q34), who had developed tonsillar lymphoma as extramedullary involvement at the initial presentation. The cytogenetic study of the cells in both bone marrow and tonsils demonstrated t(8;9)(p11;q34), despite no malignant features in the bone marrow specimens. She developed acute leukaemic transformation 8 months after diagnosis during chemotherapy for lymphoma. Although etoposide reduced the number of blasts, t(8;9)(p11,q34)bearing cells were not eradicated. Complete remission was obtained following an unrelated bone marrow transplantation. The clinical characteristics of this patient are similar to those of the patients with t(8;9)(p11;q34 or q32) or t(8;13)(p11;q11 or q12) reported previously. The unusual progression of the disease might be associated with the presence of t(8;9)(p11;q34), suggesting a part in the 8p11 myeloproliferative syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 692-695 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 92 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1996 |
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All Science Journal Classification (ASJC) codes
- Hematology
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Chronic myelomonocytic leukaemia with t(8;9)(p11;q34) in childhood : An example of the 8p11 myeloproliferative disorder? / Nakayama, Hideki; Inamitsu, Takeshi; Ohga, Shouichi; Kai, Takeshi; Suda, Masahiro; Matsuzaki, Akinobu; Ueda, Kohji.
In: British Journal of Haematology, Vol. 92, No. 3, 01.01.1996, p. 692-695.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic myelomonocytic leukaemia with t(8;9)(p11;q34) in childhood
T2 - An example of the 8p11 myeloproliferative disorder?
AU - Nakayama, Hideki
AU - Inamitsu, Takeshi
AU - Ohga, Shouichi
AU - Kai, Takeshi
AU - Suda, Masahiro
AU - Matsuzaki, Akinobu
AU - Ueda, Kohji
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We describe the case of a 10-year old girl with chronic myelomonocytic leukaemia with the chromosomal translocation t(8;9)(p11;q34), who had developed tonsillar lymphoma as extramedullary involvement at the initial presentation. The cytogenetic study of the cells in both bone marrow and tonsils demonstrated t(8;9)(p11;q34), despite no malignant features in the bone marrow specimens. She developed acute leukaemic transformation 8 months after diagnosis during chemotherapy for lymphoma. Although etoposide reduced the number of blasts, t(8;9)(p11,q34)bearing cells were not eradicated. Complete remission was obtained following an unrelated bone marrow transplantation. The clinical characteristics of this patient are similar to those of the patients with t(8;9)(p11;q34 or q32) or t(8;13)(p11;q11 or q12) reported previously. The unusual progression of the disease might be associated with the presence of t(8;9)(p11;q34), suggesting a part in the 8p11 myeloproliferative syndrome.
AB - We describe the case of a 10-year old girl with chronic myelomonocytic leukaemia with the chromosomal translocation t(8;9)(p11;q34), who had developed tonsillar lymphoma as extramedullary involvement at the initial presentation. The cytogenetic study of the cells in both bone marrow and tonsils demonstrated t(8;9)(p11;q34), despite no malignant features in the bone marrow specimens. She developed acute leukaemic transformation 8 months after diagnosis during chemotherapy for lymphoma. Although etoposide reduced the number of blasts, t(8;9)(p11,q34)bearing cells were not eradicated. Complete remission was obtained following an unrelated bone marrow transplantation. The clinical characteristics of this patient are similar to those of the patients with t(8;9)(p11;q34 or q32) or t(8;13)(p11;q11 or q12) reported previously. The unusual progression of the disease might be associated with the presence of t(8;9)(p11;q34), suggesting a part in the 8p11 myeloproliferative syndrome.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029913153&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1996.00386.x
DO - 10.1046/j.1365-2141.1996.00386.x
M3 - Article
C2 - 8616038
AN - SCOPUS:0029913153
VL - 92
SP - 692
EP - 695
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 3
ER -