Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Hiroaki Ogata, Isamu Okamoto, Goichi Yoshimoto, Teppei Obara, Kayo Ijichi, Eiji Iwama, Taishi Harada, Koichi Akashi, Yoichi Nakanishi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalRespiratory Investigation
Volume55
Issue number2
DOIs
Publication statusPublished - Mar 1 2017

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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