Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning

Kazuhito Yokoyama; Shunichi Araki; Katsuyuki Murata; Mariko Nishikitani; Tetsu Okumura; Shinichi Ishimatsu; Nobukatsu Takasu

doi:10.1016/S0928-4257(98)80040-5

Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning

Kazuhito Yokoyama, Shunichi Araki, Katsuyuki Murata, Mariko Nishikitani, Tetsu Okumura, Shinichi Ishimatsu, Nobukatsu Takasu

Institute of Decision Science for a Sustainable Society

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6-8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13-131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD.

Original language	English
Pages (from-to)	317-323
Number of pages	7
Journal	Journal of Physiology Paris
Volume	92
Issue number	3-4
DOIs	https://doi.org/10.1016/S0928-4257(98)80040-5
Publication status	Published - 1998

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Physiology (medical)

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abstract = "To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6-8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13-131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD.",

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AU - Yokoyama, Kazuhito

AU - Araki, Shunichi

AU - Murata, Katsuyuki

AU - Nishikitani, Mariko

AU - Okumura, Tetsu

AU - Ishimatsu, Shinichi

AU - Takasu, Nobukatsu

PY - 1998

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AB - To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6-8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13-131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD.

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Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning

Abstract

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