Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning

Kazuhito Yokoyama, Shunichi Araki, Katsuyuki Murata, Mariko Nishikitani, Tetsu Okumura, Shinichi Ishimatsu, Nobukatsu Takasu

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6-8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13-131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalJournal of Physiology Paris
Volume92
Issue number3-4
DOIs
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology (medical)

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