Chronic progressive spinocerebellar syndrome associated with antibodies to human T-lymphotropic virus type I

clinico-virological and magnetic resonance imaging studies

Jun-Ichi Kira, Ikuo Goto, Makoto Otsuka, Yuichi Ichiya

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The relationship between HTLV-I infection and the development of spinocerebellar degeneration (SCD) in adulthood was studied. The frequency of anti-HTLV-I antibodies among patients with SCD (8 of 43, 19%) was found to be higher than the seroprevalence rate in the northern part of Kyushu island (6%). All HTLV-I carriers with SCD showed chronic progressive cerebellar ataxia as a predominant feature and cerebellar atrophy was evident in 6 of 8 patients on magnetic resonance imaging (MRI) of the brain. However, SCD patients with anti-HTLV-I antibodies showed a significantly higher frequency of cerebral white matter lesions on brain MRI (6 of 8) and pyramidal tract signs in lower extremities (6 of 8) than did those without the antibodies (35%, P < 0.05 and 26%, P < 0.01, respectively). Moreover, the HTLV-I carriers with SCD exceeded 14 HTLV-I carriers having neither SCD nor HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) (21%, P < 0.05), and 59 HTLV-I seronegative patients without brain disorders (19%, P < 0.001) in the frequency of white matter lesions. On the other hand, the HTLV-I carriers with SCD were distinct to the HAM/TSP patients in the predominance of cerebellar involvement. Therefore, the peculiar features of cerebellar, pyramidal and white matter involvement in the HTLV-I-seropostive SCD patients as well as the increased frequency of HTLV-I infection among SCD patients suggest that this syndrome may be a distinct subtype of HTLV-I-associated neurologic diseases.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalJournal of the Neurological Sciences
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 1 1993

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Spinocerebellar Degenerations
Human T-lymphotropic virus 1
Magnetic Resonance Imaging
Viruses
Antibodies
HTLV-I Antibodies
HTLV-I Infections
Tropical Spastic Paraparesis
Cerebellar Ataxia
Pyramidal Tracts
Seroepidemiologic Studies
Brain
Brain Diseases
Nervous System Diseases
Islands
Atrophy
Lower Extremity

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Chronic progressive spinocerebellar syndrome associated with antibodies to human T-lymphotropic virus type I : clinico-virological and magnetic resonance imaging studies. / Kira, Jun-Ichi; Goto, Ikuo; Otsuka, Makoto; Ichiya, Yuichi.

In: Journal of the Neurological Sciences, Vol. 115, No. 1, 01.01.1993, p. 111-116.

Research output: Contribution to journalArticle

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abstract = "The relationship between HTLV-I infection and the development of spinocerebellar degeneration (SCD) in adulthood was studied. The frequency of anti-HTLV-I antibodies among patients with SCD (8 of 43, 19{\%}) was found to be higher than the seroprevalence rate in the northern part of Kyushu island (6{\%}). All HTLV-I carriers with SCD showed chronic progressive cerebellar ataxia as a predominant feature and cerebellar atrophy was evident in 6 of 8 patients on magnetic resonance imaging (MRI) of the brain. However, SCD patients with anti-HTLV-I antibodies showed a significantly higher frequency of cerebral white matter lesions on brain MRI (6 of 8) and pyramidal tract signs in lower extremities (6 of 8) than did those without the antibodies (35{\%}, P < 0.05 and 26{\%}, P < 0.01, respectively). Moreover, the HTLV-I carriers with SCD exceeded 14 HTLV-I carriers having neither SCD nor HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) (21{\%}, P < 0.05), and 59 HTLV-I seronegative patients without brain disorders (19{\%}, P < 0.001) in the frequency of white matter lesions. On the other hand, the HTLV-I carriers with SCD were distinct to the HAM/TSP patients in the predominance of cerebellar involvement. Therefore, the peculiar features of cerebellar, pyramidal and white matter involvement in the HTLV-I-seropostive SCD patients as well as the increased frequency of HTLV-I infection among SCD patients suggest that this syndrome may be a distinct subtype of HTLV-I-associated neurologic diseases.",
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