Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice

Peng Zhao, Tetsuya Hiramoto, Yasunari Asano, Chiharu Kubo, Nobuyuki Sudo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although accumulating clinical evidence has shown that psychological stress worsens cutaneous symptoms by exaggerating scratching behavior, how the stress affects the scratching is unclear. Therefore, we herein investigated this using an animal model of scratching. Male BALB/c mice were exposed to 1 h water avoidance stress (WAS) for ten consecutive days. Twenty-four hours after the last stress session, the mice were injected into the back of the neck with a condensation product of N-methyl-p- methoxyphenethylamine with formaldehyde (compound 48/80), and their scratching behavior was then observed for 120 min. Mast cell number in the skin and histamine and corticosterone levels in the plasma were examined. The scratching number was significantly higher in the chronic WAS group than in the control group. Both mast cell number in the skin and the peak histamine in the plasma after the compound 48/80 injection were also significantly higher in the chronic WAS group in comparison to the control group. Chronic WAS delayed the peak corticosterone plasma response to the compound 48/40 injection. These findings indicate that chronic WAS exacerbates the compound 48/80-induced scratching behavior of mice. Both the increased number of skin mast cells and delayed glucocorticoid reaction may be related to this exacerbation.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume105
DOIs
Publication statusPublished - Apr 1 2013

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p-Methoxy-N-methylphenethylamine
Dehydration
Psychological Stress
Mast Cells
Skin
Water
Corticosterone
Histamine
Cell Count
Plasmas
Control Groups
Injections
Formaldehyde
Glucocorticoids
Neck
Animal Models
Condensation
Animals

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice. / Zhao, Peng; Hiramoto, Tetsuya; Asano, Yasunari; Kubo, Chiharu; Sudo, Nobuyuki.

In: Pharmacology Biochemistry and Behavior, Vol. 105, 01.04.2013, p. 173-176.

Research output: Contribution to journalArticle

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