Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.

Akiyo Tanaka, A. Hisanaga, Miyuki Hirata, M. Omura, Y. Makita, N. Inoue, N. Ishinishi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume87
Issue number5
Publication statusPublished - Jan 1 1996

Fingerprint

Cricetinae
Lung
Control Groups
Mesocricetus
Emphysema
Arsenic
Osteogenesis
Phosphorus
Weight Gain
Hyperplasia
Pneumonia
Buffers
Phosphates
Body Weight
indium phosphide
indium arsenide
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters. / Tanaka, Akiyo; Hisanaga, A.; Hirata, Miyuki; Omura, M.; Makita, Y.; Inoue, N.; Ishinishi, N.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 87, No. 5, 01.01.1996, p. 108-115.

Research output: Contribution to journalArticle

Tanaka, A, Hisanaga, A, Hirata, M, Omura, M, Makita, Y, Inoue, N & Ishinishi, N 1996, 'Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.', Fukuoka igaku zasshi = Hukuoka acta medica, vol. 87, no. 5, pp. 108-115.
Tanaka, Akiyo ; Hisanaga, A. ; Hirata, Miyuki ; Omura, M. ; Makita, Y. ; Inoue, N. ; Ishinishi, N. / Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters. In: Fukuoka igaku zasshi = Hukuoka acta medica. 1996 ; Vol. 87, No. 5. pp. 108-115.
@article{a40f307d150b40949e84b0decee7d47f,
title = "Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.",
abstract = "Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.",
author = "Akiyo Tanaka and A. Hisanaga and Miyuki Hirata and M. Omura and Y. Makita and N. Inoue and N. Ishinishi",
year = "1996",
month = "1",
day = "1",
language = "English",
volume = "87",
pages = "108--115",
journal = "Fukuoka Acta Medica",
issn = "0016-254X",
publisher = "福岡医学会",
number = "5",

}

TY - JOUR

T1 - Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.

AU - Tanaka, Akiyo

AU - Hisanaga, A.

AU - Hirata, Miyuki

AU - Omura, M.

AU - Makita, Y.

AU - Inoue, N.

AU - Ishinishi, N.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

AB - Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

UR - http://www.scopus.com/inward/record.url?scp=0030139273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030139273&partnerID=8YFLogxK

M3 - Article

C2 - 8690334

AN - SCOPUS:0030139273

VL - 87

SP - 108

EP - 115

JO - Fukuoka Acta Medica

JF - Fukuoka Acta Medica

SN - 0016-254X

IS - 5

ER -