[Chrono-drug delivery system based on the circadian rhythm of transferrin receptor].

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin. TfR1 expression is higher in tumor cells than in normal cells. Thus, intracellular targeting using iron-saturated Tf as a ligand for TfR-mediated endocytosis has attracted attention. TfR1 in colon cancer-bearing mice exhibits a 24-hour rhythm in mRNA and protein levels. The clock-controlled gene c-MYC rhythmically activate the transcription of the TfR1 gene. In addition, the cyclical accumulation of TfR1 causes dosing time-dependent changes in the intratumoral delivery of drug by receptor-mediated endocytosis. Identification of the circadian properties of molecules that are targeted by ligand-directed DDS may aid the choice of the most appropriate time of day for their administration.

Original languageEnglish
Pages (from-to)2200-2205
Number of pages6
JournalUnknown Journal
Volume71
Issue number12
Publication statusPublished - Jan 1 2013

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circadian rhythm
Transferrin Receptors
Drug Delivery Systems
Circadian Rhythm
ligand
drug
iron
gene
tumor
targeting
cancer
Endocytosis
Iron
protein
Ligands
Drug Receptors
Transferrin
Colonic Neoplasms
Genes
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

[Chrono-drug delivery system based on the circadian rhythm of transferrin receptor]. / Naoya, Matsunaga; Okazaki, Fumiyasu; Satoru, Koyanagi; Ohdo, Shigehiro.

In: Unknown Journal, Vol. 71, No. 12, 01.01.2013, p. 2200-2205.

Research output: Contribution to journalReview article

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