Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster

Akira Matsumoto, Takehiro Motoshige, Takehide Murata, Kenji Tomioka, Teiichi Tanimura, Yoshihiko Chiba

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We have isolated a new semidominant clock mutant Toki on the second chromosome in Drosophila melanogaster. This mutant differs from the wild-type Canton-S in several properties as follows. Larger values are obtained in the phase angle difference (ψ the time from lights-off in a 24-hr light-dark cycle to an activity offset), the ratio of activity time to rest time (αrho; and the activity level. The free-running period (τ is 25.3 hr, one hour longer than in the wild-type. In the phase response curve (PRC), the ratio between the delay and the advance portion is larger and the cross-over point occurs later, although there is no difference in amplitude of the mutant's PRC (Type I). The rhythm is more sensitive to the light intensity, becoming obscure in darker condition. Toki interacts with other clock mutations, perS, perL and And, in such a way that τ s associated with these three X-linked mutations are lengthened and ψ values become smaller.

Original languageEnglish
Pages (from-to)141-155
Number of pages15
JournalJournal of Neurogenetics
Volume9
Issue number3
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

Drosophila melanogaster
Light
Mutation
Photoperiod
Chromosomes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Genetics
  • Developmental Biology
  • Neuroscience(all)

Cite this

Matsumoto, A., Motoshige, T., Murata, T., Tomioka, K., Tanimura, T., & Chiba, Y. (1994). Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster. Journal of Neurogenetics, 9(3), 141-155. https://doi.org/10.3109/01677069409167276

Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster. / Matsumoto, Akira; Motoshige, Takehiro; Murata, Takehide; Tomioka, Kenji; Tanimura, Teiichi; Chiba, Yoshihiko.

In: Journal of Neurogenetics, Vol. 9, No. 3, 01.01.1994, p. 141-155.

Research output: Contribution to journalArticle

Matsumoto, A, Motoshige, T, Murata, T, Tomioka, K, Tanimura, T & Chiba, Y 1994, 'Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster', Journal of Neurogenetics, vol. 9, no. 3, pp. 141-155. https://doi.org/10.3109/01677069409167276
Matsumoto, Akira ; Motoshige, Takehiro ; Murata, Takehide ; Tomioka, Kenji ; Tanimura, Teiichi ; Chiba, Yoshihiko. / Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster. In: Journal of Neurogenetics. 1994 ; Vol. 9, No. 3. pp. 141-155.
@article{be3aab68e4af46e585531e5f69cae330,
title = "Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster",
abstract = "We have isolated a new semidominant clock mutant Toki on the second chromosome in Drosophila melanogaster. This mutant differs from the wild-type Canton-S in several properties as follows. Larger values are obtained in the phase angle difference (ψ the time from lights-off in a 24-hr light-dark cycle to an activity offset), the ratio of activity time to rest time (αrho; and the activity level. The free-running period (τ is 25.3 hr, one hour longer than in the wild-type. In the phase response curve (PRC), the ratio between the delay and the advance portion is larger and the cross-over point occurs later, although there is no difference in amplitude of the mutant's PRC (Type I). The rhythm is more sensitive to the light intensity, becoming obscure in darker condition. Toki interacts with other clock mutations, perS, perL and And, in such a way that τ s associated with these three X-linked mutations are lengthened and ψ values become smaller.",
author = "Akira Matsumoto and Takehiro Motoshige and Takehide Murata and Kenji Tomioka and Teiichi Tanimura and Yoshihiko Chiba",
year = "1994",
month = "1",
day = "1",
doi = "10.3109/01677069409167276",
language = "English",
volume = "9",
pages = "141--155",
journal = "Journal of Neurogenetics",
issn = "0167-7063",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Chronobiological analysis of a new clock mutant, toki, in drosophila melanogaster

AU - Matsumoto, Akira

AU - Motoshige, Takehiro

AU - Murata, Takehide

AU - Tomioka, Kenji

AU - Tanimura, Teiichi

AU - Chiba, Yoshihiko

PY - 1994/1/1

Y1 - 1994/1/1

N2 - We have isolated a new semidominant clock mutant Toki on the second chromosome in Drosophila melanogaster. This mutant differs from the wild-type Canton-S in several properties as follows. Larger values are obtained in the phase angle difference (ψ the time from lights-off in a 24-hr light-dark cycle to an activity offset), the ratio of activity time to rest time (αrho; and the activity level. The free-running period (τ is 25.3 hr, one hour longer than in the wild-type. In the phase response curve (PRC), the ratio between the delay and the advance portion is larger and the cross-over point occurs later, although there is no difference in amplitude of the mutant's PRC (Type I). The rhythm is more sensitive to the light intensity, becoming obscure in darker condition. Toki interacts with other clock mutations, perS, perL and And, in such a way that τ s associated with these three X-linked mutations are lengthened and ψ values become smaller.

AB - We have isolated a new semidominant clock mutant Toki on the second chromosome in Drosophila melanogaster. This mutant differs from the wild-type Canton-S in several properties as follows. Larger values are obtained in the phase angle difference (ψ the time from lights-off in a 24-hr light-dark cycle to an activity offset), the ratio of activity time to rest time (αrho; and the activity level. The free-running period (τ is 25.3 hr, one hour longer than in the wild-type. In the phase response curve (PRC), the ratio between the delay and the advance portion is larger and the cross-over point occurs later, although there is no difference in amplitude of the mutant's PRC (Type I). The rhythm is more sensitive to the light intensity, becoming obscure in darker condition. Toki interacts with other clock mutations, perS, perL and And, in such a way that τ s associated with these three X-linked mutations are lengthened and ψ values become smaller.

UR - http://www.scopus.com/inward/record.url?scp=0028464378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028464378&partnerID=8YFLogxK

U2 - 10.3109/01677069409167276

DO - 10.3109/01677069409167276

M3 - Article

VL - 9

SP - 141

EP - 155

JO - Journal of Neurogenetics

JF - Journal of Neurogenetics

SN - 0167-7063

IS - 3

ER -