Chronopharmacokinetics of valproic acid following constant-rate administration in mice and influence of feeding schedule

J. G. Song, S. Ohdo, N. Ogawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To study the circadian rhythm in pharmacokinetics of valproic acid (VA) and influence of feeding schedule on the rhythm. Methods: Sodium valproate was administered by osmotic minipump technique (1.062 mg · h-1) and iv (50 mg · kg-1) to ICR mice fed under ad lib or time-restricted schedules to determine the time-dependent changes of VA kinetics. Results: Plasma VA concentration and clearance at steady-state showed circadian rhythms (P < 0.01). Time-restricted feeding influenced the rhythm of VA kinetics, acrophases of rhythms shifted approximately 12 h. Conclusion: Timing of dosing is important for VA kinetics and feeding schedule is one of synchronizers in VA kinetics.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalActa Pharmacologica Sinica
Volume16
Issue number2
Publication statusPublished - Jan 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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