Chronopharmacological study of KE-SI-TO components in mice

Shigehiro Ohdo, Nobuya Ogawa, Jian Guo Song, Shun Higuchi

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Abstract

Influence of dosing time on pharmacological effects and toxicity of KE-SI-TO (KST) components, as well as the role of each component in the circadian rhythms of KST, was investigated in ICR male mice under an LD (12:12) cycle. The mice given Cinnamomi Cortex (258 mg/kg, i.p.) or Paeoniae Radix (258 mg/kg, i.p.) showed a significant circadian rhythm in the time spent on the hot plate with the shortest latency at 0900 and the longest one at 0100 (p < 0.01, respectively). The mice given Cinnamomi Cortex or Glycyrrhizae Radix (129 mg/kg, i.p.) showed a significant circadian rhythm with the lowest rectal temperature (RT) at 1700 and the highest one at 0500 (p < 0.01, respectively). Cinnamomi Cortex (850 mg/kg, i.p.)- or Glycyrrhizae Radix (2500 mg/kg, i.p.)-induced toxicity showed a significant circadian rhythm with the highest mortality at 1700 and the lowest one at 0500 (p < 0.05, respectively). The rhythmic patterns of the drug-induced analgesia, hypothermia and toxicity resembled the overall rhythms occurring after KST (1000 or 6000 mg/kg, i.p.) injection. These results suggest that the circadian rhythms in actions of Cinnamomi Cortex, Paeoniae Radix and Glycyrrhizae Radix are mainly responsible for the rhythm in the effects and toxicity of KST.

Original languageEnglish
Pages (from-to)2057-2064
Number of pages8
JournalLife Sciences
Volume62
Issue number22
DOIs
Publication statusPublished - Apr 24 1998

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Circadian Rhythm
Toxicity
Paeonia
Hypothermia
Induced Hypothermia
Inbred ICR Mouse
Analgesia
cinnamomi cortex
Pharmacology
Injections
Temperature
Pharmaceutical Preparations
Mortality

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chronopharmacological study of KE-SI-TO components in mice. / Ohdo, Shigehiro; Ogawa, Nobuya; Song, Jian Guo; Higuchi, Shun.

In: Life Sciences, Vol. 62, No. 22, 24.04.1998, p. 2057-2064.

Research output: Contribution to journalArticle

Ohdo, Shigehiro ; Ogawa, Nobuya ; Song, Jian Guo ; Higuchi, Shun. / Chronopharmacological study of KE-SI-TO components in mice. In: Life Sciences. 1998 ; Vol. 62, No. 22. pp. 2057-2064.
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