Chronopharmacological study of KE-SI-TO in mice

Nobuya Ogawa, Shigehiro Ohdo, Jian Guo Song, Shun Higuchi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Influence of dosing time on pharmacological effects and toxicity of KE- SI-TO (KST), analgesic and antipyretic drug, was investigated in ICR male mice under LD (12:12) cycle. Significant circadian rhythms were demonstrated for analgesic and hypothermal effects of KST (1 g/kg, i.p.) with higher values in the dark and lower ones in the light (p<0.01, respectively). The rhythmic patterns of KST-induced analgesia and hypothermia resembled overall the rhythms occuring in the nondrugged state. Injection of KST resulted in a parallel increasing in latency to hot plate and a parallel decreasing in rectal temperature. KST (6 g/kg, i.p.)induced toxicity also showed a significant circadian rhythm with the highest mortality at 1700 and the lowest one at 0500 (p<0.05). The principles and concepts of biological rhythm should be included in the consideration of the actions of KST.

Original languageEnglish
Pages (from-to)2091-2098
Number of pages8
JournalLife Sciences
Volume60
Issue number23
DOIs
Publication statusPublished - May 2 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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