Chronopharmacological study of KE-SI-TO in mice

Nobuya Ogawa, Shigehiro Ohdo, Jian Guo Song, Shun Higuchi

Research output: Contribution to journalArticle

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Abstract

Influence of dosing time on pharmacological effects and toxicity of KE- SI-TO (KST), analgesic and antipyretic drug, was investigated in ICR male mice under LD (12:12) cycle. Significant circadian rhythms were demonstrated for analgesic and hypothermal effects of KST (1 g/kg, i.p.) with higher values in the dark and lower ones in the light (p<0.01, respectively). The rhythmic patterns of KST-induced analgesia and hypothermia resembled overall the rhythms occuring in the nondrugged state. Injection of KST resulted in a parallel increasing in latency to hot plate and a parallel decreasing in rectal temperature. KST (6 g/kg, i.p.)induced toxicity also showed a significant circadian rhythm with the highest mortality at 1700 and the lowest one at 0500 (p<0.05). The principles and concepts of biological rhythm should be included in the consideration of the actions of KST.

Original languageEnglish
Pages (from-to)2091-2098
Number of pages8
JournalLife Sciences
Volume60
Issue number23
DOIs
Publication statusPublished - May 2 1997

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Circadian Rhythm
Toxicity
Analgesics
Hypothermia
Induced Hypothermia
Antipyretics
Inbred ICR Mouse
Periodicity
Analgesia
Pharmacology
Light
Injections
Temperature
Mortality
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chronopharmacological study of KE-SI-TO in mice. / Ogawa, Nobuya; Ohdo, Shigehiro; Song, Jian Guo; Higuchi, Shun.

In: Life Sciences, Vol. 60, No. 23, 02.05.1997, p. 2091-2098.

Research output: Contribution to journalArticle

Ogawa, N, Ohdo, S, Song, JG & Higuchi, S 1997, 'Chronopharmacological study of KE-SI-TO in mice', Life Sciences, vol. 60, no. 23, pp. 2091-2098. https://doi.org/10.1016/S0024-3205(97)00196-3
Ogawa, Nobuya ; Ohdo, Shigehiro ; Song, Jian Guo ; Higuchi, Shun. / Chronopharmacological study of KE-SI-TO in mice. In: Life Sciences. 1997 ; Vol. 60, No. 23. pp. 2091-2098.
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