Chronopharmacology based on molecular clock

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chronotherapy is especially relevant, when the risk and/or intensity of the symptoms of disease vary predicably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. The effectiveness and toxicity of many drugs vary depending on dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also pharmacokinetics of medications. One approach to increasing the efficiency of pharmacotherapy is administering drugs at times during which they are best tolerated. From viewpoints of pharmaceutics, the application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nucleus; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 hr cycles. Clock genes were identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior. Clock gene regulates several disease such as cancer, metabolic syndrome and sleep etc. Therefore, we introduce an overview of the dosing time-dependent alterations in therapeutic outcome and safety of drug. The underlying mechanisms and usefulness are introduced from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalOral Therapeutics and Pharmacology
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Genes
Drug Therapy
Pharmaceutical Preparations
Sleep
Chronotherapy
Circadian Clocks
Suprachiasmatic Nucleus
Appetite
Periodicity
Drug Delivery Systems
Circadian Rhythm
Drug-Related Side Effects and Adverse Reactions
Peptic Ulcer
Arthritis
Capsules
Asthma
Heart Failure
Pharmacokinetics
Stroke
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Pharmacology
  • Pharmacology (medical)

Cite this

Chronopharmacology based on molecular clock. / Ohdo, Shigehiro.

In: Oral Therapeutics and Pharmacology, Vol. 37, No. 1, 01.01.2018, p. 1-8.

Research output: Contribution to journalArticle

@article{ce065c444ab84ec0a5fd14666f09c9d6,
title = "Chronopharmacology based on molecular clock",
abstract = "Chronotherapy is especially relevant, when the risk and/or intensity of the symptoms of disease vary predicably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. The effectiveness and toxicity of many drugs vary depending on dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also pharmacokinetics of medications. One approach to increasing the efficiency of pharmacotherapy is administering drugs at times during which they are best tolerated. From viewpoints of pharmaceutics, the application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nucleus; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 hr cycles. Clock genes were identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior. Clock gene regulates several disease such as cancer, metabolic syndrome and sleep etc. Therefore, we introduce an overview of the dosing time-dependent alterations in therapeutic outcome and safety of drug. The underlying mechanisms and usefulness are introduced from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.",
author = "Shigehiro Ohdo",
year = "2018",
month = "1",
day = "1",
doi = "10.11263/jsotp.18.02",
language = "English",
volume = "37",
pages = "1--8",
journal = "Oral Therapeutics and Pharmacology",
issn = "0288-1012",
publisher = "Japanese Society of Oral Therapeutics and Pharmacology",
number = "1",

}

TY - JOUR

T1 - Chronopharmacology based on molecular clock

AU - Ohdo, Shigehiro

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Chronotherapy is especially relevant, when the risk and/or intensity of the symptoms of disease vary predicably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. The effectiveness and toxicity of many drugs vary depending on dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also pharmacokinetics of medications. One approach to increasing the efficiency of pharmacotherapy is administering drugs at times during which they are best tolerated. From viewpoints of pharmaceutics, the application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nucleus; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 hr cycles. Clock genes were identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior. Clock gene regulates several disease such as cancer, metabolic syndrome and sleep etc. Therefore, we introduce an overview of the dosing time-dependent alterations in therapeutic outcome and safety of drug. The underlying mechanisms and usefulness are introduced from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.

AB - Chronotherapy is especially relevant, when the risk and/or intensity of the symptoms of disease vary predicably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. The effectiveness and toxicity of many drugs vary depending on dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also pharmacokinetics of medications. One approach to increasing the efficiency of pharmacotherapy is administering drugs at times during which they are best tolerated. From viewpoints of pharmaceutics, the application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nucleus; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 hr cycles. Clock genes were identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior. Clock gene regulates several disease such as cancer, metabolic syndrome and sleep etc. Therefore, we introduce an overview of the dosing time-dependent alterations in therapeutic outcome and safety of drug. The underlying mechanisms and usefulness are introduced from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.

UR - http://www.scopus.com/inward/record.url?scp=85047094705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047094705&partnerID=8YFLogxK

U2 - 10.11263/jsotp.18.02

DO - 10.11263/jsotp.18.02

M3 - Article

AN - SCOPUS:85047094705

VL - 37

SP - 1

EP - 8

JO - Oral Therapeutics and Pharmacology

JF - Oral Therapeutics and Pharmacology

SN - 0288-1012

IS - 1

ER -