Chronopharmacology focused on biological clock.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

The mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and influences a multitude of biological processes, including the sleep-wake rhythm. Clock genes are the genes that control the circadian rhythms in physiology and behavior. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. Such chronopharmacological phenomena are influenced by not only the pharmacokinetics but also pharmacodynamics of medications. Identification of a rhythmic marker for selecting dosing time will lead to improved progress and diffusion of chronopharmacotherapy. The mechanisms underlying chronopharmacological findings should be clarified from the viewpoint of clock genes. On the other hand, several drugs have an effect on circadian clock. The knowledge of interactions between circadian clock and drugs should be very useful for clinical practice. Therefore, I introduce the regulatory system of biological rhythm from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.

Original languageEnglish
Pages (from-to)3-14
Number of pages12
JournalDrug metabolism and pharmacokinetics
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

Fingerprint

Biological Clocks
Circadian Clocks
Genes
Physiological Phenomena
Biological Phenomena
Suprachiasmatic Nucleus
Periodicity
Circadian Rhythm
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Sleep
Pharmacokinetics
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Chronopharmacology focused on biological clock. / Ohdo, Shigehiro.

In: Drug metabolism and pharmacokinetics, Vol. 22, No. 1, 01.01.2007, p. 3-14.

Research output: Contribution to journalReview article

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