Churg-Strauss syndrome: A retrospective study of 11 cases from a single center in Japan

Yoshiro Horai, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Soichiro Takahama, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

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Abstract

Objective: To investigate the clinical characteristics of patients with Churg-Strauss syndrome (CSS), including symptoms, blood chemistry and immunological findings. Patients and methods: We retrospectively investigated the records of 11 patients (six female and five male) with CSS admitted to our hospital from September 2003 to October 2009. Results: Eight patients had preceding symptoms including bronchial asthma and allergic rhinitis. Seven patients showed eosinophilia. Nine patients had mononeuritis multiplex. Positive findings of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) were found in five patients. Neither clinical manifestations nor laboratory findings were correlated with positivity for MPO-ANCA. However, the MPO-ANCA-positive group showed a higher level of blood urea nitrogen and proteinuria than those negative for MPO-ANCA. Ten patients recovered after starting steroid or immunosuppressive therapy, although one patient died of unknown etiology. Conclusion: Although general assessments based on various factors such as medical history, clinical manifestation and laboratory studies are indispensable in CSS, MPO-ANCA might be useful as a predictor of renal dysfunction in patients with CSS.

Original languageEnglish
Pages (from-to)e6-e10
JournalInternational Journal of Rheumatic Diseases
Volume13
Issue number3
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology

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    Horai, Y., Miyamura, T., Hirata, A., Nakamura, M., Takahama, S., Ando, H., Minami, R., Yamamoto, M., & Suematsu, E. (2010). Churg-Strauss syndrome: A retrospective study of 11 cases from a single center in Japan. International Journal of Rheumatic Diseases, 13(3), e6-e10. https://doi.org/10.1111/j.1756-185X.2010.01479.x