Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Yoshiro Horai, Tomoya Miyamura, Soichiro Takahama, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

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6 Citations (Scopus)

Abstract

A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

Original languageEnglish
Pages (from-to)76-78
Number of pages3
JournalModern Rheumatology
Volume21
Issue number1
DOIs
Publication statusPublished - Feb 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology

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    Horai, Y., Miyamura, T., Takahama, S., Hirata, A., Nakamura, M., Ando, H., Minami, R., Yamamoto, M., & Suematsu, E. (2011). Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement. Modern Rheumatology, 21(1), 76-78. https://doi.org/10.1007/s10165-010-0341-3