Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Yoshiro Horai; Tomoya Miyamura; Soichiro Takahama; Akie Hirata; Masataka Nakamura; Hitoshi Ando; Rumi Minami; Masahiro Yamamoto; Eiichi Suematsu

doi:10.1007/s10165-010-0341-3

Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Yoshiro Horai, Tomoya Miyamura, Soichiro Takahama, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

Original language	English
Pages (from-to)	76-78
Number of pages	3
Journal	Modern Rheumatology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s10165-010-0341-3
Publication status	Published - Feb 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Rheumatology

Access to Document

10.1007/s10165-010-0341-3

Cite this

@article{b79501d66eda487a95e319d4588c0ceb,

title = "Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement",

abstract = "A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.",

author = "Yoshiro Horai and Tomoya Miyamura and Soichiro Takahama and Akie Hirata and Masataka Nakamura and Hitoshi Ando and Rumi Minami and Masahiro Yamamoto and Eiichi Suematsu",

year = "2011",

month = feb,

doi = "10.1007/s10165-010-0341-3",

language = "English",

volume = "21",

pages = "76--78",

journal = "Modern Rheumatology",

issn = "1439-7595",

publisher = "Springer Japan",

number = "1",

}

TY - JOUR

T1 - Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

AU - Horai, Yoshiro

AU - Miyamura, Tomoya

AU - Takahama, Soichiro

AU - Hirata, Akie

AU - Nakamura, Masataka

AU - Ando, Hitoshi

AU - Minami, Rumi

AU - Yamamoto, Masahiro

AU - Suematsu, Eiichi

PY - 2011/2

Y1 - 2011/2

N2 - A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

AB - A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

UR - http://www.scopus.com/inward/record.url?scp=79951953912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951953912&partnerID=8YFLogxK

U2 - 10.1007/s10165-010-0341-3

DO - 10.1007/s10165-010-0341-3

M3 - Article

C2 - 20680375

AN - SCOPUS:79951953912

SN - 1439-7595

VL - 21

SP - 76

EP - 78

JO - Modern Rheumatology

JF - Modern Rheumatology

IS - 1

ER -

Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this