Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit

Teruki Dainichi, Hiromichi Takeshita, Yoichi Moroi, Kazunori Urabe, Mariko Yoshida, Yoshiko Hisamatsu, Ayako Komai, Hong Duan, Tetsuya Koga, Takashi Hashimoto, Masutaka Furue

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cicatricial pemphigoid (CP) is an autoimmune bullous disease accompanied by mucosal lesions. The majority of patients with CP have autoantibodies against BP180. Anti-laminin 5 (epiligrin) CP is relatively rare. It is known that, in most cases, circulating autoantibodies against laminin 5 in these patients recognize the α3 and/or β3 subunits of this molecule. Here we report a case of anti-laminin 5 CP, which showed IgG autoantibodies against the γ2 subunit of laminin 5 alone. A 50-year-old woman suffered from skin blistering on the trunk and extremities and severe mucosal lesions in the eyes, oral cavities and laryngopharynx. Despite potent systemic steroids, the mucosal lesions and some parts of the skin lesions persisted. Salazosulfapyridine was of value in controlling the laryngopharyngeal lesions and persistent cutaneous blistering, and cyclophosphamide had definite effects especially on ocular lesions. Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalEuropean Journal of Dermatology
Volume15
Issue number3
Publication statusPublished - May 1 2005

Fingerprint

Benign Mucous Membrane Pemphigoid
Autoantibodies
Skin
Sulfasalazine
Hypopharynx
Cyclophosphamide
Autoimmune Diseases
Mouth
kalinin
Extremities
Immunoglobulin G
Steroids
Serum

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Dainichi, T., Takeshita, H., Moroi, Y., Urabe, K., Yoshida, M., Hisamatsu, Y., ... Furue, M. (2005). Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit. European Journal of Dermatology, 15(3), 189-193.

Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit. / Dainichi, Teruki; Takeshita, Hiromichi; Moroi, Yoichi; Urabe, Kazunori; Yoshida, Mariko; Hisamatsu, Yoshiko; Komai, Ayako; Duan, Hong; Koga, Tetsuya; Hashimoto, Takashi; Furue, Masutaka.

In: European Journal of Dermatology, Vol. 15, No. 3, 01.05.2005, p. 189-193.

Research output: Contribution to journalArticle

Dainichi, T, Takeshita, H, Moroi, Y, Urabe, K, Yoshida, M, Hisamatsu, Y, Komai, A, Duan, H, Koga, T, Hashimoto, T & Furue, M 2005, 'Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit', European Journal of Dermatology, vol. 15, no. 3, pp. 189-193.
Dainichi T, Takeshita H, Moroi Y, Urabe K, Yoshida M, Hisamatsu Y et al. Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit. European Journal of Dermatology. 2005 May 1;15(3):189-193.
Dainichi, Teruki ; Takeshita, Hiromichi ; Moroi, Yoichi ; Urabe, Kazunori ; Yoshida, Mariko ; Hisamatsu, Yoshiko ; Komai, Ayako ; Duan, Hong ; Koga, Tetsuya ; Hashimoto, Takashi ; Furue, Masutaka. / Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit. In: European Journal of Dermatology. 2005 ; Vol. 15, No. 3. pp. 189-193.
@article{b9673ea834934af6be1810391f28df99,
title = "Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit",
abstract = "Cicatricial pemphigoid (CP) is an autoimmune bullous disease accompanied by mucosal lesions. The majority of patients with CP have autoantibodies against BP180. Anti-laminin 5 (epiligrin) CP is relatively rare. It is known that, in most cases, circulating autoantibodies against laminin 5 in these patients recognize the α3 and/or β3 subunits of this molecule. Here we report a case of anti-laminin 5 CP, which showed IgG autoantibodies against the γ2 subunit of laminin 5 alone. A 50-year-old woman suffered from skin blistering on the trunk and extremities and severe mucosal lesions in the eyes, oral cavities and laryngopharynx. Despite potent systemic steroids, the mucosal lesions and some parts of the skin lesions persisted. Salazosulfapyridine was of value in controlling the laryngopharyngeal lesions and persistent cutaneous blistering, and cyclophosphamide had definite effects especially on ocular lesions. Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled.",
author = "Teruki Dainichi and Hiromichi Takeshita and Yoichi Moroi and Kazunori Urabe and Mariko Yoshida and Yoshiko Hisamatsu and Ayako Komai and Hong Duan and Tetsuya Koga and Takashi Hashimoto and Masutaka Furue",
year = "2005",
month = "5",
day = "1",
language = "English",
volume = "15",
pages = "189--193",
journal = "European Journal of Dermatology",
issn = "1167-1122",
publisher = "John Libbey Eurotext",
number = "3",

}

TY - JOUR

T1 - Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit

AU - Dainichi, Teruki

AU - Takeshita, Hiromichi

AU - Moroi, Yoichi

AU - Urabe, Kazunori

AU - Yoshida, Mariko

AU - Hisamatsu, Yoshiko

AU - Komai, Ayako

AU - Duan, Hong

AU - Koga, Tetsuya

AU - Hashimoto, Takashi

AU - Furue, Masutaka

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Cicatricial pemphigoid (CP) is an autoimmune bullous disease accompanied by mucosal lesions. The majority of patients with CP have autoantibodies against BP180. Anti-laminin 5 (epiligrin) CP is relatively rare. It is known that, in most cases, circulating autoantibodies against laminin 5 in these patients recognize the α3 and/or β3 subunits of this molecule. Here we report a case of anti-laminin 5 CP, which showed IgG autoantibodies against the γ2 subunit of laminin 5 alone. A 50-year-old woman suffered from skin blistering on the trunk and extremities and severe mucosal lesions in the eyes, oral cavities and laryngopharynx. Despite potent systemic steroids, the mucosal lesions and some parts of the skin lesions persisted. Salazosulfapyridine was of value in controlling the laryngopharyngeal lesions and persistent cutaneous blistering, and cyclophosphamide had definite effects especially on ocular lesions. Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled.

AB - Cicatricial pemphigoid (CP) is an autoimmune bullous disease accompanied by mucosal lesions. The majority of patients with CP have autoantibodies against BP180. Anti-laminin 5 (epiligrin) CP is relatively rare. It is known that, in most cases, circulating autoantibodies against laminin 5 in these patients recognize the α3 and/or β3 subunits of this molecule. Here we report a case of anti-laminin 5 CP, which showed IgG autoantibodies against the γ2 subunit of laminin 5 alone. A 50-year-old woman suffered from skin blistering on the trunk and extremities and severe mucosal lesions in the eyes, oral cavities and laryngopharynx. Despite potent systemic steroids, the mucosal lesions and some parts of the skin lesions persisted. Salazosulfapyridine was of value in controlling the laryngopharyngeal lesions and persistent cutaneous blistering, and cyclophosphamide had definite effects especially on ocular lesions. Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled.

UR - http://www.scopus.com/inward/record.url?scp=21144451649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21144451649&partnerID=8YFLogxK

M3 - Article

C2 - 15908306

AN - SCOPUS:21144451649

VL - 15

SP - 189

EP - 193

JO - European Journal of Dermatology

JF - European Journal of Dermatology

SN - 1167-1122

IS - 3

ER -