Circadian blood pressure in patients in a persistent vegetative state

Yuji Fukudome, Isao Abe, Yoshisuke Saku, Kiyoshi Matsumura, Seizo Sadoshima, Hidetuna Utunomiya, Masatoshi Fujishima

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We examined circadian variations in blood pressure, pulse rate, and other physiological variables, including hormone levels, in 16 patients in a persistent vegetative state (mean age ± SE: 66.1 ± 3.9 yr). Cerebrovascular accident was responsible for brain damage in 12 (75%) of the 16 patients. Blood pressure was measured for 24 h with an ambulatory blood pressure monitoring device. We monitored the temperature of the urinary bladder and measured urinary excretion of epinephrine, norepinephrine, 17- hydroxycorticosteroids, water, and sodium. When data were analyzed by analysis of variance, significant circadian changes were observed in body temperature and urinary excretion of hormones and sodium, but not in blood pressure or pulse rate. Individual analysis of rhythmicity using the cosinor method detected small but significant circadian variations in blood pressure and pulse rate in five of six patients who showed a simple organized response to noxious external stimuli. The disappearance of variation in blood pressure in patients in a vegetative state appeared to be related, in part, to the lack of response to external stimuli. Our findings suggest that the circadian variation in blood pressure may largely depend on external environmental factors.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume270
Issue number5 39-5
Publication statusPublished - Jun 25 1996

Fingerprint

Persistent Vegetative State
Blood Pressure
Heart Rate
Sodium
17-Hydroxycorticosteroids
Hormones
Ambulatory Blood Pressure Monitoring
Periodicity
Body Temperature
Epinephrine
Norepinephrine
Analysis of Variance
Urinary Bladder
Stroke
Equipment and Supplies
Temperature
Water
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Fukudome, Y., Abe, I., Saku, Y., Matsumura, K., Sadoshima, S., Utunomiya, H., & Fujishima, M. (1996). Circadian blood pressure in patients in a persistent vegetative state. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 270(5 39-5).

Circadian blood pressure in patients in a persistent vegetative state. / Fukudome, Yuji; Abe, Isao; Saku, Yoshisuke; Matsumura, Kiyoshi; Sadoshima, Seizo; Utunomiya, Hidetuna; Fujishima, Masatoshi.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 270, No. 5 39-5, 25.06.1996.

Research output: Contribution to journalArticle

Fukudome, Y, Abe, I, Saku, Y, Matsumura, K, Sadoshima, S, Utunomiya, H & Fujishima, M 1996, 'Circadian blood pressure in patients in a persistent vegetative state', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 270, no. 5 39-5.
Fukudome, Yuji ; Abe, Isao ; Saku, Yoshisuke ; Matsumura, Kiyoshi ; Sadoshima, Seizo ; Utunomiya, Hidetuna ; Fujishima, Masatoshi. / Circadian blood pressure in patients in a persistent vegetative state. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1996 ; Vol. 270, No. 5 39-5.
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