Circadian control of the immune system

Christoph Scheiermann, Yuya Kunisaki, Paul S. Frenette

Research output: Contribution to journalReview article

389 Citations (Scopus)


Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.

Original languageEnglish
Pages (from-to)190-198
Number of pages9
JournalNature Reviews Immunology
Issue number3
Publication statusPublished - Mar 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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