Circadian rhythm of embryotoxicity induced by sodium valproate in mice

Shigehiro Ohdo; Watanabe Hirokazu Watanabe; Ogawa Nobuya Ogawa; Yoshiyama Yuji Yoshiyama; Sugiyama Takashi Sugiyama

doi:10.1016/0926-6917(95)00024-0

Circadian rhythm of embryotoxicity induced by sodium valproate in mice

Shigehiro Ohdo, Watanabe Hirokazu Watanabe, Ogawa Nobuya Ogawa, Yoshiyama Yuji Yoshiyama, Sugiyama Takashi Sugiyama

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The influence of dosing time on embryotoxicity of valproate was investigated in ICR (Institute of Cancer Research, USA) mice under light-dark (12:12) cycle. A significant circadian rhythm was shown for embryotoxicity, with the highest value at 17:00 and the lowest at 01:00. No significant difference between injection at 17:00 and 01:00 was demonstrated for valproate concentrations in the embryo. The rhythm in the embryotoxicity seems to be related to the rhythm in the sensitivity to the drug. Embryotoxicity and valproate concentrations were significantly higher on gestational day 13 than day 7. The timing of drug administration (i.e, gestational stage and circadian phase) appears to be essential in the study of embryotoxicity of valproate in mice.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	European Journal of Pharmacology: Environmental Toxicology and
Volume	293
Issue number	3
DOIs	https://doi.org/10.1016/0926-6917(95)00024-0
Publication status	Published - Oct 6 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology
Pollution

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10.1016/0926-6917(95)00024-0

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Circadian rhythm of embryotoxicity induced by sodium valproate in mice. / Ohdo, Shigehiro; Hirokazu Watanabe, Watanabe; Nobuya Ogawa, Ogawa; Yuji Yoshiyama, Yoshiyama; Takashi Sugiyama, Sugiyama.

In: European Journal of Pharmacology: Environmental Toxicology and, Vol. 293, No. 3, 06.10.1995, p. 281-285.

Research output: Contribution to journal › Article › peer-review

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abstract = "The influence of dosing time on embryotoxicity of valproate was investigated in ICR (Institute of Cancer Research, USA) mice under light-dark (12:12) cycle. A significant circadian rhythm was shown for embryotoxicity, with the highest value at 17:00 and the lowest at 01:00. No significant difference between injection at 17:00 and 01:00 was demonstrated for valproate concentrations in the embryo. The rhythm in the embryotoxicity seems to be related to the rhythm in the sensitivity to the drug. Embryotoxicity and valproate concentrations were significantly higher on gestational day 13 than day 7. The timing of drug administration (i.e, gestational stage and circadian phase) appears to be essential in the study of embryotoxicity of valproate in mice.",

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