Circulating angiotensin ii deteriorates left ventricular function with sympathoexcitation via brain angiotensin ii receptor

keisuke shinohara, Takuya Kishi, Yoshitaka Hirooka, Kenji Sunagawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Sympathoexcitation contributes to the progression of heart failure. Activation of brain angiotensin II type 1 receptors (AT1R) causes central sympathoexcitation. Thus, we assessed the hypothesis that the increase in circulating angiotensin II comparable to that reported in heart failure model affects cardiac function through the central sympathoexcitation via activating AT1R in the brain. In Sprague-Dawley rats, the subcutaneous infusion of angiotensin II for 14 days increased the circulating angiotensin II level comparable to that reported in heart failure model rats after myocardial infarction. In comparison with the control, angiotensin II infusion increased 24 hours urinary norepinephrine excretion, and systolic blood pressure. Angiotensin II infusion hypertrophied left ventricular (LV) without changing chamber dimensions while increased end-diastolic pressure. The LV pressure-volume relationship indicated that angiotensin II did not impact on the end-systolic elastance, whereas significantly increased end-diastolic elastance. Chronic intracerebroventricular infusion of AT1R blocker, losartan, attenuated these angiotensin II-induced changes. In conclusion, circulating angiotensin II in heart failure is capable of inducing sympathoexcitation via in part AT1R in the brain, subsequently leading to LV diastolic dysfunction.

Original languageEnglish
Article numbere12514
JournalPhysiological Reports
Volume3
Issue number8
DOIs
Publication statusPublished - Jan 1 2015

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Angiotensin Receptors
Angiotensins
Left Ventricular Function
Angiotensin II
Brain
Angiotensin Type 1 Receptor
Heart Failure
Blood Pressure
Intraventricular Infusions
Angiotensin II Type 1 Receptor Blockers
Subcutaneous Infusions
Losartan
Left Ventricular Dysfunction
Ventricular Pressure
Sprague Dawley Rats
Norepinephrine
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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Circulating angiotensin ii deteriorates left ventricular function with sympathoexcitation via brain angiotensin ii receptor. / shinohara, keisuke; Kishi, Takuya; Hirooka, Yoshitaka; Sunagawa, Kenji.

In: Physiological Reports, Vol. 3, No. 8, e12514, 01.01.2015.

Research output: Contribution to journalArticle

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