Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

Takaaki Masuda, Yoshiaki Shinden, Miwa Noda, Hiroki Ueo, Qingjiang Hu, Yukihiro Yoshikawa, Yusuke Tsuruda, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Shinji Ohno, Koshi Mimori

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12 Citations (Scopus)

Abstract

Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for "Precision medicine". This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgicallytreated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.

Original languageEnglish
Pages (from-to)4515-4523
Number of pages9
JournalAnticancer research
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Masuda, T., Shinden, Y., Noda, M., Ueo, H., Hu, Q., Yoshikawa, Y., Tsuruda, Y., Kuroda, Y., Ito, S., Eguchi, H., Ohno, S., & Mimori, K. (2018). Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer. Anticancer research, 38(8), 4515-4523. https://doi.org/10.21873/anticanres.12755