Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

Takaaki Masuda; Yoshiaki Shinden; Miwa Noda; Hiroki Ueo; Qingjiang Hu; Yukihiro Yoshikawa; Yusuke Tsuruda; Yohsuke Kuroda; Shuhei Ito; Hidetoshi Eguchi; Shinji Ohno; Koshi Mimori

doi:10.21873/anticanres.12755

Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

Takaaki Masuda, Yoshiaki Shinden, Miwa Noda, Hiroki Ueo, Qingjiang Hu, Yukihiro Yoshikawa, Yusuke Tsuruda, Yohsuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Shinji Ohno, Koshi Mimori

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Abstract

Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for "Precision medicine". This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgicallytreated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.

Original language	English
Pages (from-to)	4515-4523
Number of pages	9
Journal	Anticancer research
Volume	38
Issue number	8
DOIs	https://doi.org/10.21873/anticanres.12755
Publication status	Published - Aug 2018

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.12755

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@article{d86e0254ac694700b2160fbaab507ec8,

title = "Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer",

abstract = "Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for {"}Precision medicine{"}. This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgicallytreated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.",

author = "Takaaki Masuda and Yoshiaki Shinden and Miwa Noda and Hiroki Ueo and Qingjiang Hu and Yukihiro Yoshikawa and Yusuke Tsuruda and Yohsuke Kuroda and Shuhei Ito and Hidetoshi Eguchi and Shinji Ohno and Koshi Mimori",

note = "Funding Information: The Authors thank Dr. Tyler Lahusen for helpful comments and English proofreading. The Authors also thank K. Oda, M. Kasagi, S. Sakuma, N. Mishima and T. Kawano for their excellent technical assistance. This work was supported in part by the following grants and foundations: Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Science Research (Grant Numbers JP16K07177, JP16K10543, JP16K19197, JP17K16454, JP17K16521, JP17K10593 and JP17K19608); OITA Cancer Research Foundation; Daiwa Securities Health Foundation; Grant-in-Aid for Scientific Research on Innovative Areas (15H0912); Priority Issue on Post-K computer (hp170227) (hp170227, hp160219); JSPS KAKENHI (15H05707); Eli Lilly Japan K.K. Grant; Japanese Foundation for Multidisciplinary Treatment of Cancer. Publisher Copyright: {\textcopyright} 2018 International Institute of Anticancer Research. All rights reserved.",

year = "2018",

month = aug,

doi = "10.21873/anticanres.12755",

language = "English",

volume = "38",

pages = "4515--4523",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "8",

}

TY - JOUR

T1 - Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

AU - Masuda, Takaaki

AU - Shinden, Yoshiaki

AU - Noda, Miwa

AU - Ueo, Hiroki

AU - Hu, Qingjiang

AU - Yoshikawa, Yukihiro

AU - Tsuruda, Yusuke

AU - Kuroda, Yohsuke

AU - Ito, Shuhei

AU - Eguchi, Hidetoshi

AU - Ohno, Shinji

AU - Mimori, Koshi

N1 - Funding Information: The Authors thank Dr. Tyler Lahusen for helpful comments and English proofreading. The Authors also thank K. Oda, M. Kasagi, S. Sakuma, N. Mishima and T. Kawano for their excellent technical assistance. This work was supported in part by the following grants and foundations: Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Science Research (Grant Numbers JP16K07177, JP16K10543, JP16K19197, JP17K16454, JP17K16521, JP17K10593 and JP17K19608); OITA Cancer Research Foundation; Daiwa Securities Health Foundation; Grant-in-Aid for Scientific Research on Innovative Areas (15H0912); Priority Issue on Post-K computer (hp170227) (hp170227, hp160219); JSPS KAKENHI (15H05707); Eli Lilly Japan K.K. Grant; Japanese Foundation for Multidisciplinary Treatment of Cancer. Publisher Copyright: © 2018 International Institute of Anticancer Research. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for "Precision medicine". This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgicallytreated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.

AB - Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for "Precision medicine". This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgicallytreated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence-free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.

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UR - http://www.scopus.com/inward/citedby.url?scp=85050800934&partnerID=8YFLogxK

U2 - 10.21873/anticanres.12755

DO - 10.21873/anticanres.12755

M3 - Article

C2 - 30061217

AN - SCOPUS:85050800934

SN - 0250-7005

VL - 38

SP - 4515

EP - 4523

JO - Anticancer Research

JF - Anticancer Research

IS - 8

ER -

Circulating Pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

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