Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes

Yoshio Izumi, Daisuke Yabe, Ataru Taniguchi, Mitsuo Fukushima, Yoshikatsu Nakai, Masaya Hosokawa, Takahide Okumura, Kazuko Nin, Kazunari Matsumoto, Fusanori Nishimura, Shoichiro Nagasaka, Yutaka Seino

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Aims: Chronic low-grade inflammation and/or obesity are suggested to induce chronic kidney disease (CKD) in patients with type 2 diabetes. This cross-sectional study was performed to investigate the relationship between inflammatory biomarkers and CKD in non-obese patients with type 2 diabetes. Methods: 106 non-obese Japanese patients with type 2 diabetes were recruited for the measurement of GFR, TNF, HMW adiponectin, leptin, hsCRP and some variables including urinary albumin. BMI, serum creatinine, and urinary albumin levels were 22.2±0.2kg/m2 (17.1-24.9kg/m2), 0.76±0.02mg/dl (0.39-1.38mg/dl), 40.4±4.3mg/gCr (1.6-195.0mg/gCr), respectively. They were stratified into two groups based on the value of eGFR: low eGFR (eGFR<60ml/min/1.73m2) and normal eGFR (eGFR>60ml/min/1.73m2). Logistic regression analysis was used for statistical analysis. Results: Whereas univariate logistic regression analysis showed that gender, diabetes duration, triglyceride, HDL cholesterol, uric acid, urinary albumin, and soluble TNF receptors (sTNF-R1, sTNF-R2) are associated with the development of stage 3 CKD, multivariate logistic regression analysis revealed that sTNF-R2 (Odds ratio 1.003, 95% confidence interval 1.000 to 1.005, P= 0.030) showed significant associations with the development of stage 3 CKD. Conclusions: Circulating TNF receptor 2 is an independent risk factor for CKD in non-obese Japanese patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume99
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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