Circulating vitamin D and colorectal adenomas in Japanese men

Ryota Takahashi, Tetsuya Mizoue, Toshie Otake, Jin Fukumoto, Osamu Tajima, Shinji Tabata, Hiroshi Abe, Ohnaka Keizo, Suminori Kono

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Accumulating evidence suggests that vitamin D has anticarcinogenic effects. However, it is unclear whether the nutrient is involved in the early stage of colorectal carcinogenesis. We examined the association between circulating vitamin D concentrations and colorectal adenomas in Japanese men. The study subjects comprised 656 cases of colorectal adenomas and 648 controls with normal colonoscopy among male self defense officials receiving a pre-retirement health examination between 1997 and 2004. Plasma or serum levels of 25-hydroxyvitamin D [25(OH)D] were measured using a radioimmunoassay method. Logistic regression analysis was used to obtain odds ratios (OR) and 95% confidence intervals (CI) with adjustment for potential confounding variables. Overall, there was no measurable association between circulating 25(OH)D concentrations and colorectal adenomas. When the analysis was restricted to subjects whose blood was taken during the winter season (November-April), the prevalence odds of colorectal adenomas for the highest versus lowest quartile of 25(OH)D was statistically significantly decreased (OR = 0.58; 95% CI = 0.34-0.99). The reduction was more pronounced for the rectum (OR = 0.22) and distal colon (OR = 0.47) than for proximal colon (OR = 0.70). During the summer season (May-October), higher levels of 25(OH)D were associated with an increased odds of small, but not large, adenomas. The present study adds to evidence that high levels of circulating vitamin D measured during darker season is associated with decreased prevalence of adenomas in the distal sites of the colorectum.

Original languageEnglish
Pages (from-to)1695-1700
Number of pages6
JournalCancer Science
Volume101
Issue number7
DOIs
Publication statusPublished - Jul 1 2010

Fingerprint

Vitamin D
Adenoma
Odds Ratio
Colon
Anticarcinogenic Agents
Confidence Intervals
Confounding Factors (Epidemiology)
Retirement
Colonoscopy
Rectum
Radioimmunoassay
Carcinogenesis
Logistic Models
Regression Analysis
Food
Health
Serum

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Takahashi, R., Mizoue, T., Otake, T., Fukumoto, J., Tajima, O., Tabata, S., ... Kono, S. (2010). Circulating vitamin D and colorectal adenomas in Japanese men. Cancer Science, 101(7), 1695-1700. https://doi.org/10.1111/j.1349-7006.2010.01575.x

Circulating vitamin D and colorectal adenomas in Japanese men. / Takahashi, Ryota; Mizoue, Tetsuya; Otake, Toshie; Fukumoto, Jin; Tajima, Osamu; Tabata, Shinji; Abe, Hiroshi; Keizo, Ohnaka; Kono, Suminori.

In: Cancer Science, Vol. 101, No. 7, 01.07.2010, p. 1695-1700.

Research output: Contribution to journalArticle

Takahashi, R, Mizoue, T, Otake, T, Fukumoto, J, Tajima, O, Tabata, S, Abe, H, Keizo, O & Kono, S 2010, 'Circulating vitamin D and colorectal adenomas in Japanese men', Cancer Science, vol. 101, no. 7, pp. 1695-1700. https://doi.org/10.1111/j.1349-7006.2010.01575.x
Takahashi R, Mizoue T, Otake T, Fukumoto J, Tajima O, Tabata S et al. Circulating vitamin D and colorectal adenomas in Japanese men. Cancer Science. 2010 Jul 1;101(7):1695-1700. https://doi.org/10.1111/j.1349-7006.2010.01575.x
Takahashi, Ryota ; Mizoue, Tetsuya ; Otake, Toshie ; Fukumoto, Jin ; Tajima, Osamu ; Tabata, Shinji ; Abe, Hiroshi ; Keizo, Ohnaka ; Kono, Suminori. / Circulating vitamin D and colorectal adenomas in Japanese men. In: Cancer Science. 2010 ; Vol. 101, No. 7. pp. 1695-1700.
@article{b285afc45aad462ea6cc3cad6522b1d5,
title = "Circulating vitamin D and colorectal adenomas in Japanese men",
abstract = "Accumulating evidence suggests that vitamin D has anticarcinogenic effects. However, it is unclear whether the nutrient is involved in the early stage of colorectal carcinogenesis. We examined the association between circulating vitamin D concentrations and colorectal adenomas in Japanese men. The study subjects comprised 656 cases of colorectal adenomas and 648 controls with normal colonoscopy among male self defense officials receiving a pre-retirement health examination between 1997 and 2004. Plasma or serum levels of 25-hydroxyvitamin D [25(OH)D] were measured using a radioimmunoassay method. Logistic regression analysis was used to obtain odds ratios (OR) and 95{\%} confidence intervals (CI) with adjustment for potential confounding variables. Overall, there was no measurable association between circulating 25(OH)D concentrations and colorectal adenomas. When the analysis was restricted to subjects whose blood was taken during the winter season (November-April), the prevalence odds of colorectal adenomas for the highest versus lowest quartile of 25(OH)D was statistically significantly decreased (OR = 0.58; 95{\%} CI = 0.34-0.99). The reduction was more pronounced for the rectum (OR = 0.22) and distal colon (OR = 0.47) than for proximal colon (OR = 0.70). During the summer season (May-October), higher levels of 25(OH)D were associated with an increased odds of small, but not large, adenomas. The present study adds to evidence that high levels of circulating vitamin D measured during darker season is associated with decreased prevalence of adenomas in the distal sites of the colorectum.",
author = "Ryota Takahashi and Tetsuya Mizoue and Toshie Otake and Jin Fukumoto and Osamu Tajima and Shinji Tabata and Hiroshi Abe and Ohnaka Keizo and Suminori Kono",
year = "2010",
month = "7",
day = "1",
doi = "10.1111/j.1349-7006.2010.01575.x",
language = "English",
volume = "101",
pages = "1695--1700",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Circulating vitamin D and colorectal adenomas in Japanese men

AU - Takahashi, Ryota

AU - Mizoue, Tetsuya

AU - Otake, Toshie

AU - Fukumoto, Jin

AU - Tajima, Osamu

AU - Tabata, Shinji

AU - Abe, Hiroshi

AU - Keizo, Ohnaka

AU - Kono, Suminori

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Accumulating evidence suggests that vitamin D has anticarcinogenic effects. However, it is unclear whether the nutrient is involved in the early stage of colorectal carcinogenesis. We examined the association between circulating vitamin D concentrations and colorectal adenomas in Japanese men. The study subjects comprised 656 cases of colorectal adenomas and 648 controls with normal colonoscopy among male self defense officials receiving a pre-retirement health examination between 1997 and 2004. Plasma or serum levels of 25-hydroxyvitamin D [25(OH)D] were measured using a radioimmunoassay method. Logistic regression analysis was used to obtain odds ratios (OR) and 95% confidence intervals (CI) with adjustment for potential confounding variables. Overall, there was no measurable association between circulating 25(OH)D concentrations and colorectal adenomas. When the analysis was restricted to subjects whose blood was taken during the winter season (November-April), the prevalence odds of colorectal adenomas for the highest versus lowest quartile of 25(OH)D was statistically significantly decreased (OR = 0.58; 95% CI = 0.34-0.99). The reduction was more pronounced for the rectum (OR = 0.22) and distal colon (OR = 0.47) than for proximal colon (OR = 0.70). During the summer season (May-October), higher levels of 25(OH)D were associated with an increased odds of small, but not large, adenomas. The present study adds to evidence that high levels of circulating vitamin D measured during darker season is associated with decreased prevalence of adenomas in the distal sites of the colorectum.

AB - Accumulating evidence suggests that vitamin D has anticarcinogenic effects. However, it is unclear whether the nutrient is involved in the early stage of colorectal carcinogenesis. We examined the association between circulating vitamin D concentrations and colorectal adenomas in Japanese men. The study subjects comprised 656 cases of colorectal adenomas and 648 controls with normal colonoscopy among male self defense officials receiving a pre-retirement health examination between 1997 and 2004. Plasma or serum levels of 25-hydroxyvitamin D [25(OH)D] were measured using a radioimmunoassay method. Logistic regression analysis was used to obtain odds ratios (OR) and 95% confidence intervals (CI) with adjustment for potential confounding variables. Overall, there was no measurable association between circulating 25(OH)D concentrations and colorectal adenomas. When the analysis was restricted to subjects whose blood was taken during the winter season (November-April), the prevalence odds of colorectal adenomas for the highest versus lowest quartile of 25(OH)D was statistically significantly decreased (OR = 0.58; 95% CI = 0.34-0.99). The reduction was more pronounced for the rectum (OR = 0.22) and distal colon (OR = 0.47) than for proximal colon (OR = 0.70). During the summer season (May-October), higher levels of 25(OH)D were associated with an increased odds of small, but not large, adenomas. The present study adds to evidence that high levels of circulating vitamin D measured during darker season is associated with decreased prevalence of adenomas in the distal sites of the colorectum.

UR - http://www.scopus.com/inward/record.url?scp=77954653491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954653491&partnerID=8YFLogxK

U2 - 10.1111/j.1349-7006.2010.01575.x

DO - 10.1111/j.1349-7006.2010.01575.x

M3 - Article

VL - 101

SP - 1695

EP - 1700

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 7

ER -