cis-Hinokiresinol, a norlignan from Anemarrhena asphodeloides, inhibits angiogenic response in vitro and in vivo

Sei Joon Jeong, Ryuichi Higuchi, Mayumi Ono, Michihiko Kuwano, Youn Chul Kim, Tomofumi Miyamoto

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

cis-Hinokiresinol (CHR) is a norlignan constituent from Anemarrhena asphodeloides BUNGE (Liliaceae), which shows hyaluronidase inhibitory activity. In the present studies, we have demonstrated that CHR selectively inhibited endothelial cell proliferation compared with cancer cells, and especially basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. Furthermore, endothelial cell migration and tube formation, two important steps in the angiogenic process, were also inhibited by CHR. Moreover, CHR reduced the vessel growth induced by VEGF in the mouse corneal neovascularization model. These results suggest that CHR may prove useful for the development of a novel angiogenesis inhibitor.

Original languageEnglish
Pages (from-to)1721-1724
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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