Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

Takashi Kimitsuki, Takashi Nakagawa, Kazutaka Hisashi, Shizuo Komune, Sohtaro Komiyama

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×10-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalHearing Research
Volume71
Issue number1-2
DOIs
Publication statusPublished - Dec 1993

All Science Journal Classification (ASJC) codes

  • Sensory Systems

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