Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells

Takashi Kimitsuki, Takashi Nakagawa, Kazutaka Hisashi, Shizuo Komune, Sohtaro Komiyama

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose-and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×10-3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalHearing Research
Volume71
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1993

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Auditory Hair Cells
Transducers
Cisplatin
Patch-Clamp Techniques
Electrodes

All Science Journal Classification (ASJC) codes

  • Sensory Systems

Cite this

Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells. / Kimitsuki, Takashi; Nakagawa, Takashi; Hisashi, Kazutaka; Komune, Shizuo; Komiyama, Sohtaro.

In: Hearing Research, Vol. 71, No. 1-2, 01.01.1993, p. 64-68.

Research output: Contribution to journalArticle

Kimitsuki, Takashi ; Nakagawa, Takashi ; Hisashi, Kazutaka ; Komune, Shizuo ; Komiyama, Sohtaro. / Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells. In: Hearing Research. 1993 ; Vol. 71, No. 1-2. pp. 64-68.
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