Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1

Shinjiro Maruyama, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cistanche salsa (C.A. Meyer) is a parasitic plant that is used as an oriental medicinal tonic in Japan. In this study we show that the C. salsa extract dialysate (CSD), which was prepared by removing the low-molecular-weight constituents from the extract using a 3,500 Da molecular-weight-cut-off dialysis membrane, enhanced IgM production in the human B cell line BALL-1. At 100 µg/ml, CSD was shown to be able to increase IgM production 1.8-fold with the added effect of slightly inducing cell proliferation. Intracellular IgM production was also increased upon treatment with CSD. These results suggest that the high-molecular-weight constituents in C. salsa is able to activate BALL-1 extracellularly and enhance IgM production.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalJournal of Traditional Medicines
Volume24
Issue number6
DOIs
Publication statusPublished - Jan 1 2007

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Cistanche
Immunoglobulin M
Dialysis Solutions
B-Lymphocytes
Cell Line
Molecular Weight
Dialysis
Japan
Cell Proliferation
Membranes

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1. / Maruyama, Shinjiro; Yamada, Koji; Tachibana, Hirofumi.

In: Journal of Traditional Medicines, Vol. 24, No. 6, 01.01.2007, p. 209-211.

Research output: Contribution to journalArticle

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