Class switching from γ3 to γ2b in a murine pre-B cell line

Tani Yoshihiko, Sugiyama Haruo, Maeda Toyoki, Miyake Seigou, Oka Yoshihiro, Ogawa Hiroyasu, Komori Toshihisa, Soma Toshihiro, Kishimoto Susumu

Research output: Contribution to journalArticlepeer-review

Abstract

Class switching from γ3 to γ2b production at pre-B cell stage was observed in an Abelson virus-transformed murine immature cell line that is able to perform VH to DJH recombinations followed by class switch recombinations. A series of Southern blotting experiments indicates that the class switching from γ3 to γ2b was mediated by the deletion mechanism of the intervening CH genes on the expressed chromosome and that the break points in the switch recombinations might be different from each other among six independent switching events from γ3 to γ2b. This in vitro switching system should provide us with much information on the mechanisms of class switch recombination.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalMolecular Immunology
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology

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