Class-switching from μ to γ3 or γ2b production at pre-B cell stage

H. Sugiyami, T. Maeda, S. Akira, S. Kishimoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

An Abelson virus-transformed murine pre-B cell line class-switched from μ to γ3 or γ2b at the pre-b stage during culture. A class-swtich was mediated by the deletion mechanism of the intervening C(H) genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to γ2b production.

Original languageEnglish
Pages (from-to)3092-3097
Number of pages6
JournalJournal of Immunology
Volume136
Issue number8
Publication statusPublished - Jan 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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