Classification method for heterogeneity in monoclonal cell population

S. Aburatani, K. Tashiro, S. Kuhara

Research output: Contribution to journalConference article

Abstract

Monoclonal cell populations are known to be composed of heterogeneous subpopulations, thus complicating the data analysis. To gain clear insights into the mechanisms of cellular systems, biological data from a homogeneous cell population should be obtained. In this study, we developed a method based on Latent Profile Analysis (LPA) combined with Confirmatory Factor Analysis (CFA) to divide mixed data into classes, depending on their heterogeneity. In general cluster analysis, the number of measured points is a constraint, and thereby the data must be classified into fewer groups than the number of samples. By our newly developed method, the measured data can be divided into groups depending on their latent effects, without constraints. Our method is useful to clarify all types of omics data, including transcriptome, proteome and metabolic information.

Original languageEnglish
Article number012077
JournalJournal of Physics: Conference Series
Volume633
Issue number1
DOIs
Publication statusPublished - Sep 21 2015
Event4th International Conference on Mathematical Modeling in Physical Sciences, IC-MSquare 2015 - Mykonos, Greece
Duration: Jun 5 2015Jun 8 2015

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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