Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP

M. Iijima, M. Yamamoto, M. Hirayama, F. Tanaka, M. Katsuno, K. Mori, H. Koike, N. Hattori, K. Arimura, M. Nakagawa, H. Yoshikawa, K. Hayasaka, O. Onodera, M. Baba, H. Yasuda, T. Saito, M. Nakazato, K. Nakashima, J. Kira, R. KajiN. Oka, G. Sobue

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49 Citations (Scopus)

Abstract

To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy (CIDP), the authors conducted a multicenter study on 312 patients with CIDP (199 responders and 113 nonresponders). Muscle atrophy and decreased compound muscle action potential were pronounced in nonresponders of IVIg. Male gender, longer disease duration, and slow progression of symptoms were also associated with IVIg unresponsiveness. Features suggesting axonal dysfunction in peripheral nerves indicated IVIg unresponsiveness in CIDP.

Original languageEnglish
Pages (from-to)1471-1475
Number of pages5
JournalNeurology
Volume64
Issue number8
DOIs
Publication statusPublished - Apr 26 2005

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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    Iijima, M., Yamamoto, M., Hirayama, M., Tanaka, F., Katsuno, M., Mori, K., Koike, H., Hattori, N., Arimura, K., Nakagawa, M., Yoshikawa, H., Hayasaka, K., Onodera, O., Baba, M., Yasuda, H., Saito, T., Nakazato, M., Nakashima, K., Kira, J., ... Sobue, G. (2005). Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP. Neurology, 64(8), 1471-1475. https://doi.org/10.1212/01.WNL.0000158680.89323.F8